67924-03-2Relevant articles and documents
Biocompatible Ionic Liquid Promote One-Pot Synthesis of 2-Amino-4H-Chromenes Under Ambient Conditions
Zhu, Anlian,Li, Qixing,Feng, Wanlu,Fan, Dongshuang,Li, Lingjun
, p. 720 - 733 (2020/08/07)
Abstract: The synthesis of 2-amino-4H-chromenes through one-pot multicomponent reactions has received great attention due to the high atom efficiency and the broad bioactivities of the products. Here, the catalytic performances of a series of functional ionic liquids towards this type of reaction were investigated and the results showed that the ionic liquid, choline acetate ([Choline][Ac]), could efficiently promote this reactions under room temperature without the necessary of organic solvents. The reaction is easy to be conducted and the following work-up procedures are very simple. The pure products can be obtained through extraction and washing procedures, no column separation procedures are needed. Intriguingly, this reaction system can be easily scaled up to multi-gram, suggesting its perspective in industrial applications. In addition, the ionic liquid [Choline][Ac] can be easily prepared from cheap and biocompatible materials, and it can be feasibly recycled and reutilized for at least five cycles. Graphic Abstract: Various aldehydes, malononitrile and activated phenols could be converted to thecorresponding 2-amino-4H-chromenes with good to excellent isolated yields underthe catalysis of choline acetate at room temperature. [Figure not available: see fulltext.]
Cytotoxicity of protic ionic liquids towards the HaCat cell line derived from human skin
Abraham, Amanda N.,Arunkumar, Radhika,Drummond, Calum J.,Greaves, Tamar L.,Shukla, Ravi
, (2020/07/03)
In this work we have investigated the toxicity of 10 PILs, consisting of ethyl-, ethanol-, diethanol- and triethanolammonium cations paired with nitrate, formate, acetate and glycolate anions. Their toxicity was quantified by the EC50 values of each of these PILs towards HaCat cells, which are derived from human skin cells. Additional salts and solvents were used for comparison including DMSO, choline chloride, potassium nitrate, sodium acetate and ethanol to distinguish if the toxicity changes were due to ionicity, short chain amphiphilic behaviour, or specific ion effects. The toxicity followed the general trend of choline chloride acetate containing PILs DMSO sodium acetate ethanol nitrate containing PILs or salt. Ethanolammonium acetate and ethylammonium acetate were identified as having the lowest toxicities of the PILs, being slightly more toxic than choline chloride or DMSO. Overall the toxicity was found to be highly dependent on the cation and anion combination, with the anion having a stronger affect. It was evident that the PILs can be tailored to vary their toxicities, and this is expected to be dependent on which cell lines are used.
The hydrophilic ionic liquid at room temperature and its use
-
Paragraph 0105; 0106, (2019/09/11)
PROBLEM TO BE SOLVED: To provide a novel ionic liquid that is liquid at a room temperature and is hydrophilic, particularly water-soluble, and use thereof.SOLUTION: This invention provides a hydrophilic room-temperature ionic liquid including a cation and an anion, the cation being a quaternary ammonium cation of the formula (I), and the anion being a carboxylate anion, where R represents a 1-5C straight-chain or branched-chain alkylene group, and n represents an integer of 1-3.
