6798-34-1

Basic information

• Product Name: 2,2,2-Trichlor-1-hydroxy-N-benzyloxycarbonyl-ethylamin
• Synonyms: 2,2,2-Trichlor-1-hydroxy-N-benzyloxycarbonyl-ethylamin
• CAS NO: 6798-34-1
• Molecular Weight: 298.553
• Mol File: 6798-34-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,2,2-Trichlor-1-hydroxy-N-benzyloxycarbonyl-ethylamin(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-Trichlor-1-hydroxy-N-benzyloxycarbonyl-ethylamin(6798-34-1)
• EPA Substance Registry System: 2,2,2-Trichlor-1-hydroxy-N-benzyloxycarbonyl-ethylamin(6798-34-1)

Safety Data

• Hazardous Substances Data: 6798-34-1(Hazardous Substances Data)

Upstream product

• 302-17-0 chloral hydrate 
• 621-84-1 O-benzyl carbamate 
• 75-87-6 chloral 

Downstream Products

• 6780-32-1 2,2,2-Trichlor-1-acetoxy-N-benzyloxycarbonyl-ethylamin 
• 6780-22-9 2,2,2-Trichlor-1-benzylamino-1-benzyloxycarbonylamino-ethan 
• 6780-29-6 2,2,2,2',2',2'-Hexachlor-1,1'-bis-benzyloxycarbonylamino-diethylether 
• 6797-67-7 2,2,2-Trifluor-1-(4-nitro-phenylmercapto)-N-benzyloxycarbonyl-ethylamin 
• 6780-73-0 N-(2,2,2-Trichlor-1-benzyloxycarbonylamino-ethyl)-L-valinmethylester 
• 6797-66-6 N-(2,2,2-Trichlor-1-benzyloxycarbonylamino-ethyl)-glycin-ethylester 
• 6780-33-2 2,2,2-Trichlor-1-benzoyloxy-N-benzyloxycarbonyl-ethylamin 
• 47373-13-7 N-(2,2,2-Trichlor-1-benzyloxycarbonylamino-ethyl)-L-valin 
• 6780-28-5 2,2,2-Trichlor-1-ethoxy-N-benzyloxycarbonyl-ethylamin 
• 6780-20-7 2,2,2-Trichlor-1-benzyloxycarbonylamino-ethylamin 
• 126442-13-5 (2R,4S)-4-Methyl-2-trichloromethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 126442-12-4 (1-Allyloxy-2,2,2-trichloro-ethyl)-carbamic acid benzyl ester 
• 136401-36-0 [(R)-2,2,2-Trichloro-1-((S)-5-oxo-2,5-dihydro-furan-2-yl)-ethyl]-carbamic acid benzyl ester 
• 136401-36-0 [(R)-2,2,2-Trichloro-1-((R)-5-oxo-2,5-dihydro-furan-2-yl)-ethyl]-carbamic acid benzyl ester 

Relevant articles and documents

Discovery of a dual tubulin polymerization and cell division cycle 20 homologue inhibitor via structural modification on apcin

Apcin is one of the few compounds that have been previously reported as a Cdc20 specific inhibitor, although Cdc20 is a very promising drug target. We reported here the design, synthesis, and biological evaluations of 2,2,2-trichloro-1-aryl carbamate derivatives as Cdc20 inhibitors. Among these derivatives, compound 9f was much more efficient than the positive compound apcin in inhibiting cancer cell growth, but it had approximately the same binding affinity with apcin in SPR assays. It is possible that another mechanism of action might exist. Further evidence demonstrated that compound 9f also inhibited tubulin polymerization, disorganized the microtubule network, and blocked the cell cycle at the M phase with changes in the expression of cyclins. Thus, it induced apoptosis through the activation of caspase-3 and PARP. In addition, compound 9f inhibited cell migration and invasion in a concentration-dependent manner. These results provide guidance for developing the current series as potential new anticancer therapeutics.

Expedient synthesis of perhaloaldehyde N-acyl hemiaminals

Various perhaloaldehyde N-acyl hemiaminals 1 are readily prepared in high yields by condensation of amides 7 with easily available perhaloaldehyde O-ethyl hemiacetals 8 or hydrates 9 in the presence of 5 A molecular sieves.