68084-17-3

Basic information

• Product Name: BENZENEACETIC ACID, 2,4-DINITRO-, ETHYL ESTER
• Synonyms: BENZENEACETIC ACID, 2,4-DINITRO-, ETHYL ESTER;ethyl 2,4-dinitrophenylacetate;2,4-Dinitrobenzeneacetic acid ethyl ester;2,4-Dinitrophenylacetic acid ethyl ester;Einecs 268-429-8;Ethyl 2-(2,4-dinitrophenyl)acetate;GLXVIYXAYZPDSM-UHFFFAOYSA-N
• CAS NO: 68084-17-3
• Molecular Formula: C₁₀H₁₀N₂O₆
• Molecular Weight: 254.2
• EINECS: 268-429-8
• Mol File: 68084-17-3.mol
• Article Data: 12

Chemical Properties

• Melting Point: 37 °C
• Boiling Point: 373.4°Cat760mmHg
• Flash Point: 167.4°C
• Appearance: /
• Density: 1.393g/cm³
• Vapor Pressure: 8.97E-06mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: BENZENEACETIC ACID, 2,4-DINITRO-, ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: BENZENEACETIC ACID, 2,4-DINITRO-, ETHYL ESTER(68084-17-3)
• EPA Substance Registry System: BENZENEACETIC ACID, 2,4-DINITRO-, ETHYL ESTER(68084-17-3)

Safety Data

• Hazardous Substances Data: 68084-17-3(Hazardous Substances Data)

Usage

General Description

Benzeneacetic acid, 2,4-dinitro-, ethyl ester is a chemical compound commonly known as ethyl 2,4-dinitrophenylacetate. It is an aromatic compound with a nitro group, and it is commonly used as a reagent in organic synthesis and as a flavoring agent in the food industry. It is also used as an intermediate in the production of various pharmaceuticals and dyes. The compound is considered to be moderately toxic and may cause irritation to the skin, eyes, and respiratory system upon exposure. It is important to handle and store this chemical with caution and in accordance with safety regulations.

InChI:InChI=1/C10H10N2O6/c1-2-18-10(13)5-7-3-4-8(11(14)15)6-9(7)12(16)17/h3-4,6H,2,5H2,1H3

Upstream product

• 99-65-0 meta-dinitrobenzene 
• 623-48-3 ethyl iodoacetae 
• 123-75-1 pyrrolidine 
• 124089-63-0 ethyl 2,4-dinitrophenylacetoacetate 
• 110-91-8 morpholine 
• 64-17-5 ethanol 
• 105-39-5 chloroacetic acid ethyl ester 
• 107-10-8 propylamine 
• 1226527-03-2 (benzothiazole-2-sulfonyl)-(2,4-dinitro-phenyl)-acetic acid ethyl ester 
• 103-82-2 phenylacetic acid 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 5465-68-9 2-(2,4-dinitrophenyl)-3-oxobutyric acid ethyl ester 
• 124-68-5 2-Amino-2-methyl-1-propanol 
• 75-08-1 ethanethiol 

Downstream Products

• 681464-32-4 N-(2-methoxy-indol-6-yl)-N-methyl-toluene-4-sulfonamide 
• 681464-35-7 N-(2-oxo-indolin-6-yl)-toluene-4-sulfonamide 
• 58605-01-9 6-acetamidoindolin-2-one 
• 681464-31-3 (2-methoxy-indol-6-yl)-methyl-amine 
• 5833-18-1 ethyl 2,2-bis(2,4-dinitrophenyl)acetate 

Relevant articles and documents

An atom economical method for the direct synthesis of quinoline derivatives from substituted o-nitrotoluenes

A highly efficient one-pot procedure for the preparation of substituted quinolines from substituted o-nitrotoluenes with electron-withdrawing groups and olefins (acrylic esters and acrylonitriles) using a cesium catalyst has been developed. A plausible [2+4] cycloaddition mechanism is proposed. This method uses nitroaromatic compounds as the starting materials to give quinoline derivatives in good to high yields under mild conditions with no transition metal catalysis. It provides an atom economical pathway for the synthesis of quinoline derivatives which could be used in industrial processes.

Transition-metal-free formal sonogashira coupling and α-carbonyl arylation reactions

Transition-metal-free formal Sonogashira coupling and α-carbonyl arylation reactions have been developed. These transformations are based on the nucleophilic aromatic substitution (SNAr) of β-carbonyl sulfones to electron-deficient aryl fluorides, producing a key intermediate that, depending on the reaction conditions, gives the aromatic alkynes or α-aryl carbonyl compounds. The development of these reactions is presented and, based on investigations under basic and acidic conditions, mechanisms have been proposed. To develop the formal disclosed that expands the reaction concept. The scope of these reactions is demonstrated for the synthesis of Sonogashira and α-carbonyl arylated products from a range of electron-deficient aryl fluorides with a variety of functional groups and aryl-, heteroaryl-, alkyl-, and alkoxy-substituted sulfone nucleophiles. These transition-metal-free reactions complement the metal-catalyzed versions in terms of substitution patterns, simplicity, and reaction conditions.

Six membered amino-amide derivatives an angiogenisis inhibitors

The present invention relates to six membered amino-amide derivatives, processes for their preparation, pharmaceutical compositions containing them as active ingredient, methods for the treatment of disease states associated with angiogenesis and/or increased vascular permeability, to their use as medicaments and to their use in the manufacture of medicaments for use in the production of antiangiogenic and/or vascular permeability reducing effects in warm-blooded animals such as humans.