680988-08-3Relevant articles and documents
Coordination-Driven Self-Assembly of Ionic Irregular Hexagonal Metallamacrocycles via an Organometallic Clip and Their Cytotoxicity Potency
Bhowmick, Sourav,Jana, Achintya,Singh, Khushwant,Gupta, Prerak,Gangrade, Ankit,Mandal, Biman B.,Das, Neeladri
, p. 3615 - 3625 (2018)
Two new irregular hexagons (6 and 7) were synthesized from a pyrazine motif containing an organometallic acceptor clip [bearing platinum(II) centers] and different neutral donor ligands (4,4′-bipyridine or pyrazine) using a coordination-driven self-assemb
Pyrazine based Pt(II) bis-alkynyl organometallic complexes: Synthesis, characterization, and cytotoxic effect on A549 human lung carcinoma cells
Bhowmick, Sourav,Jana, Achintya,Marri, Subba R.,Gupta, Prerak,Behera,Mandal, Biman B.,Das, Neeladri
, (2017)
A facile and efficient synthesis of a series of five new pyrazine-based organometallic complexes is being reported. The complexes (2–6) have been fully characterized. Molecules 2, 3 and 6 were structurally characterized by single crystal X-ray crystallographic analyses. Additionally, anticancer properties of these organometallic complexes have been studied against A549 human lung carcinoma cells. Biological studies suggest that complex 5 (with pendant pyridine moieties) exhibited maximal growth inhibitory cytotoxic effect even at lower concentration (nearly 0.5–1?μM) whereas the other four compounds (2, 3, 4 and 6) were non-toxic below 1?μM concentration. Two complexes (4 and 6) were effective only at higher doses (approx 30?μM) while the remaining two organometallic complexes (2 and 3) were able to inhibit 50% cell growth at slightly lower concentration (nearly 10?μM). As far as IC50 is concerned, 5 exhibited a minimum value ranging between 3–5?μM which is comparable with cisplatin under similar conditions.
Single-site modifications and their effect on the folding stability of m-phenylene ethynylene oligomers
Goto, Hirofumi,Heemstra, Jennifer M.,Hill, David J.,Moore, Jeffrey S.
, p. 889 - 892 (2007/10/03)
(Equation presented) The folded structure of a m-phenylene ethynylene oligomer is tolerant to single-site modifications to both the backbone sequence and end groups. The helical structure is reinforced by multiple noncovalent interactions, allowing the ol
