68120-72-9

Basic information

• Product Name: 1-(3,4-DICHLORO-PHENYL)-PENTAN-1-ONE
• Synonyms: 1-(3,4-DICHLORO-PHENYL)-PENTAN-1-ONE;1-Pentanone, 1-(3,4-dichlorophenyl)-
• CAS NO: 68120-72-9
• Molecular Formula: C₁₁H₁₂Cl₂O
• Molecular Weight: 231.11838
• Mol File: 68120-72-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 330.7±27.0 °C(Predicted)
• Appearance: /
• Density: 1.188±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(3,4-DICHLORO-PHENYL)-PENTAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-DICHLORO-PHENYL)-PENTAN-1-ONE(68120-72-9)
• EPA Substance Registry System: 1-(3,4-DICHLORO-PHENYL)-PENTAN-1-ONE(68120-72-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 68120-72-9(Hazardous Substances Data)

Usage

General Description

1-(3,4-Dichloro-phenyl)-pentan-1-one is a chemical compound characterized by the presence of chlorine, hence it belongs to the class of organic compounds known as chloroalkanes. As implied by its name, it contains a pentan-1-one group attached to a 3,4-dichlorophenyl group. This chemical is often used in a variety of applications in chemistry due to its versatility and reactivity. However, it's important to handle it with care as it can be hazardous in certain conditions. Its physical properties, reactivity, and safety measures should always be considered when using this compound in any experiments or industrial applications.

Upstream product

• 6574-99-8 3,4-dichloro-benzonitrile 
• 693-04-9 butyl magnesium bromide 
• 638-29-9 n-valeryl chloride 
• 95-50-1 1,2-dichloro-benzene 
• 766-84-7 3-chloro-benzonitrile 
• 151169-75-4 3,4-dichlophenylboronic acid 

Downstream Products

• 850352-15-7 2-bromo-1-(3,4-dichlorophenyl)pentan-1-one 
• 1033815-33-6 (3,4-dichlorophenyl)-(3-(R)-propylpyrrolidin-3-yl)methanone 

Relevant articles and documents

Aminothiazole derivatives

The invention relates to aminothiazole heterocyclic derivatives, a preparation method thereof and an application of the aminothiazole heterocyclic derivatives in preparation of drugs for treating or preventing progressive cognitive disorder and/or amnesia diseases.

(3,4-DICHLORO-PHENYL)-((S)-3-PROPYL-PYRROLIDIN-3-YL)-METHANONE HYDROCHLORIDE AND MANUFACTURING PROCESSES

The present invention is concerned with a novel process for the preparation of a compound of formula I and its hydrates, as well as with a crystall polymorph thereof. The compounds of formula (I) and the corresponding hydrates are pharmaceutically active substances.

Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction

A series of bupropion (1a) analogues (1b-1ff) were synthesized, and their in vitro and in vivo pharmacological properties evaluated with the goal of developing a 1a analogue that had better properties for treating addictions. Their in vitro pharmacological properties were examined by [3H] dopamine ([3H]DA), [3H]serotonin ([3H]5HT), and [3H]norepinephrine ([3H]NE) uptake inhibition studies, and by binding studies at the dopamine, serotonin, and norepinephrine transporters using [125I]RTI-55 in cloned transporters. Several analogues showed increased [3H]DAuptake inhibition with reduced or little change in [3H]5HT and [3H]NE uptake inhibition relative to bupropion. Thirty-five analogues were evaluated in a 1 h locomotor activity observation test and 32 in an 8 h locomotor activity observation test and compared to the locomotor activity of cocaine. Twenty-four analogues were evaluated for generalization to cocaine drug discrimination after i.p. administration, and twelve analogues were tested in a time course cocaine discrimination study using oral administration. 2-(N-Cyclopropylamino)-3- chloropropiophenone (1x) had the most favorable in vitro efficacy and in vivo pharmacological profile for an indirect dopamine agonist pharmacotherapy for treating cocaine, methamphetamine, nicotine, and other drugs of abuse addiction. 2009 American Chemical Society.