68123-31-9

Basic information

• Product Name: benzofuran-3,6,7-triol triacetate
• Synonyms: benzofuran-3,6,7-triol triacetate;Triacetic acid 3,6,7-benzofurantriyl ester;3,6,7-Benzofurantriol, 3,6,7-triacetate;3,6,7-Benzofurantriol, triacetate;3,6,7-Triacetoxycoumarone;Einecs 268-549-0
• CAS NO: 68123-31-9
• Molecular Formula: C₁₄H₁₂O₇
• Molecular Weight: 292.24088
• EINECS: 268-549-0
• Mol File: 68123-31-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 419.3°C at 760 mmHg
• Flash Point: 207.4°C
• Appearance: /
• Density: 1.333g/cm³
• Vapor Pressure: 3.07E-07mmHg at 25°C
• Refractive Index: 1.555
• CAS DataBase Reference: benzofuran-3,6,7-triol triacetate(CAS DataBase Reference)
• NIST Chemistry Reference: benzofuran-3,6,7-triol triacetate(68123-31-9)
• EPA Substance Registry System: benzofuran-3,6,7-triol triacetate(68123-31-9)

Safety Data

• Hazardous Substances Data: 68123-31-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H12O7/c1-7(15)19-11-5-4-10-12(20-8(2)16)6-18-13(10)14(11)21-9(3)17/h4-6H,1-3H3

Upstream product

• 87-66-1 2-hydroxyresorcinol 
• 6272-27-1 6,7-dihydroxybenzofuran-3[2H]-one 
• 108-24-7 acetic anhydride 
• 17345-68-5 ω-chloro-2,3,4-trihydroxyacetophenone 
• 107-14-2 chloroacetonitrile 
• 75-36-5 acetyl chloride 

Downstream Products

• 42484-95-7 2,3-dihydro-benzofuran-6,7-diol 
• 89939-91-3 6,7-Dihydroxy-cumaron 
• 68123-32-0 6,7-diacetoxy-2,3-dihydro-benzofuran 
• 96924-90-2 2,3-dihydro-3,6,7-triacetoxybenzofuran 

Relevant articles and documents

Specificity of Calreticulin Transacetylase to acetoxy derivatives of benzofurans: Effect on the activation of platelet Nitric Oxide Synthase

Calreticulin Transacetylase (CRTAase) catalyzes the transfer of acetyl group(s) from polyphenolic acetates (PAs) to functional proteins, such as Glutathione S-transferase (GST), NADPH Cytochrome c reductase and Nitric Oxide Synthase (NOS) resulting in the modulation of biological activities. A comparison of the specificities of the acetoxy derivatives of coumarins, biscoumarins, chromones, flavones, isoflavones and xanthones has been carried out earlier by us with an aim to study the effect of nature and position of the acetoxy groups on the benzenoid ring and the position of the carbonyl group with respect to oxygen/nitrogen heteroatom for the catalytic activity of CRTAase. In this communication for the first time, we have studied the influence of differently substituted benzofurans on the CRTAase activity to study the effect of the replacement of pyran ring of coumarin with furan ring, presence of carbonyl at C-3, substitution of C-3 carbonyl group with acetoxy group and presence of various substituents (OAc/OH/Cl) on the benzenoid ring. It was observed that acetoxy derivatives of benzofurans lead to inhibition of ADP induced platelet aggregation by the activation of platelet Nitric Oxide Synthase catalyzed by CRTAase. Accordingly, the formation of NO in platelets by 3-oxo-2,3-dihydrobenzofuran-6,7-diyl diacetate (3a) was found to be comparable with that of model polyphenolic acetate (PA), 7,8-diacetoxy-4-methylcoumarin (DAMC).

Anti-atherosclerotic 6,7-dihydro-7,7-disubstituted-khellin analogs

The present specification provides novel analogs of khellin. These analogs are all useful as antiatherosclerotic agents. Particularly, the present specification provides 4-methoxy, 9-methoxy, or 4,9-dimethoxy-6,7-dihydro-7,7-disubstituted-5H-furo[3,2-g][1]benzopyran-5-ones.