681282-72-4Relevant articles and documents
The synthesis of 14C-labeled, 13CD 2-labeled saxagliptin, and its 13CD2-labeled 5-hydroxy metabolite
Tran, Scott B.,Maxwell, Brad D.,Cao, Kai,Bonacorsi, Samuel J.
, p. 136 - 140 (2014)
14C-labeled saxagliptin, 13CD2-labeled saxagliptin, and its 13CD2-labeled 5-hydroxy metabolite were synthesized to further support development of the compound for biological studies. This paper describes new syntheses leading to the desired compounds. A total of 3.0 mCi of 14C-labeled saxagliptin was obtained with a specific activity of 53.98 μCi/mg (17.13 mCi/mmol). The radiochemical purity determined by HPLC was 99.29%, and the overall radiochemical yield was 3.0% based upon 100 mCi of [14C]CH2I2 starting material. By following similar synthetic routes, 580.0 mg of 13CD2-labeled saxagliptin and 153.1 mg of 13CD2-labeled 5-hydroxysaxagliptin metabolite were prepared. Copyright
ADAMANTYGLYCINE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND METHODS
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Page/Page column 36-37, (2008/06/13)
Compounds are provided having the formula (I) [Chemical Structure] wherein: n is 0, 1 or 2; m is 0, 1 or 2; the sum of n + m less then or equal to 2; the dashed bonds forming a cyclopropyl ring can only be present when Y is CH; X is H or CN; Y is CH, CH2, CHF, CF2, O, S, SO, or SO2; and A is adamantyl. Further provided are methods of using such compounds for the treatment of diabetes and related diseases, and to pharmaceutical compositions containing such compounds.