681425-33-2

Basic information

• Product Name: (S)-[(1α,5α,6α)-3-(4-{5-[(2,2-difluoroacetylamino)methyl]-2-oxooxazolidin-3-yl}-2,6-difluorophenyl)-3-azabicyclo[3.1.0]hex-6-yl]carbamic acid tert-butyl ester
• Synonyms: (S)-[(1α,5α,6α)-3-(4-{5-[(2,2-difluoroacetylamino)methyl]-2-oxooxazolidin-3-yl}-2,6-difluorophenyl)-3-azabicyclo[3.1.0]hex-6-yl]carbamic acid tert-butyl ester
• CAS NO: 681425-33-2
• Molecular Weight: 502.466
• Mol File: 681425-33-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-[(1α,5α,6α)-3-(4-{5-[(2,2-difluoroacetylamino)methyl]-2-oxooxazolidin-3-yl}-2,6-difluorophenyl)-3-azabicyclo[3.1.0]hex-6-yl]carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-[(1α,5α,6α)-3-(4-{5-[(2,2-difluoroacetylamino)methyl]-2-oxooxazolidin-3-yl}-2,6-difluorophenyl)-3-azabicyclo[3.1.0]hex-6-yl]carbamic acid tert-butyl ester(681425-33-2)
• EPA Substance Registry System: (S)-[(1α,5α,6α)-3-(4-{5-[(2,2-difluoroacetylamino)methyl]-2-oxooxazolidin-3-yl}-2,6-difluorophenyl)-3-azabicyclo[3.1.0]hex-6-yl]carbamic acid tert-butyl ester(681425-33-2)

Safety Data

• Hazardous Substances Data: 681425-33-2(Hazardous Substances Data)

Upstream product

• 66684-58-0 3,4,5-trifluoronitrobenzene 
• 681425-31-0 (R)-methanesulfonic acid 3-[4-((1α,5α,6α)-6-tert-butoxycarbonylamino-3-azabicyclo[3.1.0]hex-3-yl)-3,5-difluorophenyl]-2-oxooxazolidin-5-ylmethyl ester 
• 681425-28-5 [(1α,5α,6α)-3-(4-benzyloxycarbonylamino-2,6-difluorophenyl)-3-azabicyclo[3.1.0]hex-6-yl]carbamic acid tert-butyl ester 
• 828252-97-7 (R)-{(1α,5α,6α)-3-[4-(5-azidomethyl-2-oxooxazolidin-3-yl)-2,6-difluorophenyl]-3-azabicyclo[3.1.0]hex-6-yl}carbamic acid tert-butyl ester 
• 504437-38-1 (R)-{(1α,5α,6α)-3-[2,6-difluoro-4-(5-hydroxymethyl-2-oxooxazolidin-3-yl)phenyl]-3-azabicyclo[3.1.0]hex-6-yl}carbamic acid tert-butyl ester 
• 504438-19-1 [(1α,5α,6α)-3-(2,6-difluoro-4-nitrophenyl)-3-azabicyclo[3.1.0]hex-6-yl]carbamic acid tert-butyl ester 
• 681425-29-6 [(1R,5S,6S)-3-(4-Amino-2,6-difluoro-phenyl)-3-aza-bicyclo[3.1.0]hex-6-yl]-carbamic acid tert-butyl ester 

Downstream Products

• 681424-59-9 N-[((5S)-3-{4-[exo-(1R,5S)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-3,5-difluorophenyl}-2-oxo-1,3-oxazolidin-5-yl)methyl]-2,2-difluoroacetamide hydrochloride 

Relevant articles and documents

Conformational constraint in oxazolidinone antibacterials. Synthesis and structure-activity studies of (azabicyclo[3.1.0]hexylphenyl)oxazolidinones

The oxazolidinones are a new class of synthetic antibacterials effective against a broad range of pathogenic Gram-positive bacteria, including multi-drug-resistant strains. Linezolid is the first drug from this class to reach the market and has become an