6817-41-0

Basic information

• Product Name: Isoliensinine
• Synonyms: Isoliensinine;(+)-Isoliensinin;(1R)-1,2,3,4-Tetrahydro-1-[[4-hydroxy-3-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]phenyl]methyl]-6-methoxy-2-methyl-7-isoquinolinol
• CAS NO: 6817-41-0
• Molecular Formula: C37H42N2O6
• Molecular Weight: 610.747
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 6817-41-0.mol
• Article Data: 0

Chemical Properties

• Melting Point: 69-71℃
• Boiling Point: 723.1 °C at 760 mmHg
• Flash Point: 391.1 °C
• Appearance: /
• Density: 1.218
• Vapor Pressure: 1.32E-21mmHg at 25°C
• Refractive Index: 1.618
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.28±0.45(Predicted)
• CAS DataBase Reference: Isoliensinine(CAS DataBase Reference)
• NIST Chemistry Reference: Isoliensinine(6817-41-0)
• EPA Substance Registry System: Isoliensinine(6817-41-0)

Safety Data

• Hazardous Substances Data: 6817-41-0(Hazardous Substances Data)

Usage

Description

Tomita and his co-workers have obtained this bisisoquinoline alkaloid from the embryo of the seeds of Nelumbo nucifera Gaertn. The base has [α]29D + 49.3° (Me2CO) and - 43.3° (CHC13 ). The hydrochloride tetrahydrate forms colourless crystals, m.p. l85-6°C (dry); the perchlorate monohydrate has m.p. 200-3°C (dry); [α]22D - 70° (Me2CO) and the styphnate of the O,O-dimethyl ether, also crystalline, has m.p. l33-5°C; [α]27D - 81.5° (Me2CO). Three methoxyl, two hydroxyl and two methylimino groups are present.

Uses

(+)-Isoliensinine is an alkaloid which displays activation of AMP-activated kinase and regulation of PPARγ receptors.

References

Tomita et aI., Tetrahedron Lett., 2637,3374 (1964)

InChI:InChI=1/C37H42N2O6/c1-38-15-13-26-20-36(44-5)37(22-29(26)30(38)16-23-6-9-27(42-3)10-7-23)45-35-18-24(8-11-32(35)40)17-31-28-21-33(41)34(43-4)19-25(28)12-14-39(31)2/h6-11,18-22,30-31,40-41H,12-17H2,1-5H3/t30-,31-/m1/s1