681807-25-0Relevant articles and documents
Direct anti-selective asymmetric hydrogenation of α-amino-β-keto esters through dynamic kinetic resolution using Ru-axially chiral phosphine catalysts-stereoselective synthesis of anti-β-hydroxy-α-amino acids
Makino, Kazuishi,Goto, Takayuki,Hiroki, Yasuhiro,Hamada, Yasumasa
experimental part, p. 2816 - 2828 (2009/06/28)
The asymmetric hydrogenation of α-amino-β-keto esters using ruthenium (Ru) anti-selectively proceeds via a dynamic kinetic resolution to afford anti-β-hydroxy-α-amino acids with high enantiomeric purities, which are important chiral building blocks for the synthesis of medicines and natural products. A mechanistic investigation has revealed that the Ru-catalyzed asymmetric hydrogenation takes place via the hydrogenation of the double bond in the enol tautomer of the substrate.
Stereoselective synthesis of anti-β-hydroxy-α-amino acids through dynamic kinetic resolution
Makino, Kazuishi,Goto, Takayuki,Hiroki, Yasuhiro,Hamada, Yasumasa
, p. 882 - 884 (2007/10/03)
Upping the anti: Asymmetric anti-selective hydrogenation of α-amino-β-keto esters through dynamic kinetic resolution has been achieved for the first time by using the Ru-binap catalyst. The reaction affords important anti-β-hydroxy-α-amino acids with 74-9
