68208-23-1 Usage
Description
3-AMINO-3-P-TOLYL-PROPAN-1-OL, also known as 3-Amino-3-(4-methylphenyl)propan-1-ol, is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals. It is characterized by its amino and p-tolyl functional groups, which contribute to its reactivity and potential applications in the medical field.
Uses
Used in Pharmaceutical Industry:
3-AMINO-3-P-TOLYL-PROPAN-1-OL is used as an intermediate in the synthesis of 4-arylcyclophosphamide, a potential antitumor agent. Its role in the production of this compound highlights its importance in the development of novel cancer treatments.
As an intermediate, 3-AMINO-3-P-TOLYL-PROPAN-1-OL plays a vital role in the preparation of pharmaceuticals with potential antitumor properties. Its unique structure allows for further chemical modifications and reactions, making it a valuable building block in the synthesis of various therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 68208-23-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,2,0 and 8 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 68208-23:
(7*6)+(6*8)+(5*2)+(4*0)+(3*8)+(2*2)+(1*3)=131
131 % 10 = 1
So 68208-23-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H15NO/c1-8-2-4-9(5-3-8)10(11)6-7-12/h2-5,10,12H,6-7,11H2,1H3
68208-23-1Relevant articles and documents
Base-induced Sommelet–Hauser rearrangement of N-(α-(2-oxyethyl)branched)benzylic glycine ester-derived ammonium salts via a chelated intermediate
Baba, Souya,Hirano, Kazuki,Tayama, Eiji
supporting information, (2020/03/13)
The base-induced Sommelet–Hauser (S–H) rearrangement of N-(α-branched)benzylic glycine ester-derived ammonium salts 1 was investigated. When the α-branched substituent was a simple alkyl, such as a methyl or butyl, desired S–H rearrangement product 2 was obtained in low yield with formation of the [1,2] Stevens rearranged 4 and Hofmann eliminated products 5 and 6. However, when the α-branched substituent had a 2-oxy moiety, such as 2-acetoxyethyl or 2-benzoyloxyethyl, the yields of 2 were improved. These results could be explained by formation of chelated intermediate C that stabilizes the carbanionic ylide, and the subsequent initial dearomative [2,3] sigmatropic rearrangement would be accelerated. The existence of C was supported by mechanistic experiments. This enhancement effect is not very strong or effective; however, it will expand the synthetic usefulness of ammonium ylide rearrangements.
