68208-24-2

Basic information

• Product Name: 3-AMINO-3-(P-METHOXYPHENYL)-1-PROPANOL
• Synonyms: DL-BETA-(4-METHOXYPHENYL)ALANINOL;3-AMINO-3-(4-METHOXYPHENYL)-1-PROPANOL;3-AMINO-3-(4-METHOXY-PHENYL)-PROPAN-1-OL;3-AMINO-3-(P-METHOXYPHENYL)-1-PROPANOL;RARECHEM AM LA 0065;3-(4-METHOXYPHENYL)-DL-BETA-ALANINOL ;3-AMINO-3-(P-METHOXYPHENYL)-1-PROPANOL 98%;3-Amino-3-(p-methoxyphenyl)-1-propanol,98%
• CAS NO: 68208-24-2
• Molecular Formula: C₁₀H₁₅NO₂
• Molecular Weight: 181.23
• Mol File: 68208-24-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 82-86 °C
• Boiling Point: 314.35°C (rough estimate)
• Flash Point: 155.9 °C
• Appearance: /
• Density: 1.0918 (rough estimate)
• Vapor Pressure: 5.14E-05mmHg at 25°C
• Refractive Index: 1.5464 (estimate)
• Storage Temp.: 0-6°C
• CAS DataBase Reference: 3-AMINO-3-(P-METHOXYPHENYL)-1-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-3-(P-METHOXYPHENYL)-1-PROPANOL(68208-24-2)
• EPA Substance Registry System: 3-AMINO-3-(P-METHOXYPHENYL)-1-PROPANOL(68208-24-2)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 45-36/37/39-26
• Hazardous Substances Data: 68208-24-2(Hazardous Substances Data)

Usage

Chemical Properties

white powder

InChI:InChI=1/C10H15NO2/c1-13-9-4-2-8(3-5-9)10(11)6-7-12/h2-5,10,12H,6-7,11H2,1H3

Upstream product

• 5678-45-5 3-amino-3-(4-methoxyphenyl)propionic acid 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 1004619-84-4 3-chloro-1-(4-methoxyphenyl)propan-1-amine 
• 1431839-31-4 N-(2,5-difluorobenzyl)-6-{[3-hydroxy-1-(4-methoxy-phenyl)propyl]amino}pyridazine-3-carboxamide 

Relevant articles and documents

Base-induced Sommelet–Hauser rearrangement of N-(α-(2-oxyethyl)branched)benzylic glycine ester-derived ammonium salts via a chelated intermediate

The base-induced Sommelet–Hauser (S–H) rearrangement of N-(α-branched)benzylic glycine ester-derived ammonium salts 1 was investigated. When the α-branched substituent was a simple alkyl, such as a methyl or butyl, desired S–H rearrangement product 2 was obtained in low yield with formation of the [1,2] Stevens rearranged 4 and Hofmann eliminated products 5 and 6. However, when the α-branched substituent had a 2-oxy moiety, such as 2-acetoxyethyl or 2-benzoyloxyethyl, the yields of 2 were improved. These results could be explained by formation of chelated intermediate C that stabilizes the carbanionic ylide, and the subsequent initial dearomative [2,3] sigmatropic rearrangement would be accelerated. The existence of C was supported by mechanistic experiments. This enhancement effect is not very strong or effective; however, it will expand the synthetic usefulness of ammonium ylide rearrangements.