68269-83-0 Usage
Description
3-Amino-N,N-diethylbenzamide is an organic compound with the chemical formula C11H16N2O. It is a derivative of benzamide, featuring an amino group and two diethylamine substituents attached to the benzene ring. 3-AMINO-N,N-DIETHYLBENZAMIDE is known for its potential applications in the pharmaceutical and chemical industries due to its unique structural properties.
Uses
Used in Pharmaceutical Industry:
3-Amino-N,N-diethylbenzamide is used as a pharmaceutical intermediate for the synthesis of various drugs and medicinal compounds. Its unique structure allows it to serve as a building block in the development of new pharmaceuticals, potentially leading to the discovery of novel treatments for various diseases and conditions.
Used in Organic Synthesis:
In the field of organic synthesis, 3-Amino-N,N-diethylbenzamide is utilized as a reagent in various chemical processes. Its presence can facilitate the formation of desired products or intermediates, making it a valuable component in the synthesis of complex organic molecules.
Used in Chemical Research:
3-Amino-N,N-diethylbenzamide is also employed in chemical research as a model compound for studying the properties and reactions of benzamide derivatives. This can provide insights into the behavior of similar compounds and contribute to the advancement of organic chemistry and related fields.
Check Digit Verification of cas no
The CAS Registry Mumber 68269-83-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,2,6 and 9 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 68269-83:
(7*6)+(6*8)+(5*2)+(4*6)+(3*9)+(2*8)+(1*3)=170
170 % 10 = 0
So 68269-83-0 is a valid CAS Registry Number.
InChI:InChI=1/C11H16N2O/c1-3-13(4-2)11(14)9-6-5-7-10(12)8-9/h5-8H,3-4,12H2,1-2H3
68269-83-0Relevant articles and documents
Structure-Based Discovery of Novel and Selective 5-Hydroxytryptamine 2B Receptor Antagonists for the Treatment of Irritable Bowel Syndrome
Zhou, Yu,Ma, Jing,Lin, Xingyu,Huang, Xi-Ping,Wu, Kaichun,Huang, Niu
, p. 707 - 720 (2016)
Here we employed structure-based ligand discovery techniques to explore a recently determined crystal structure of the 5-hydroxytryptamine 2B (5-HT2B) receptor. Ten compounds containing a novel chemical scaffold were identified; among them, seven molecules were active in cellular function assays with the most potent one exhibiting an IC50 value of 27.3 nM. We then systematically probed the binding characteristics of this scaffold by designing, synthesizing, and testing a series of structural modifications. The structure-activity relationship studies strongly support our predicted binding model. The binding profiling across a panel of 11 5-HT receptors indicated that these compounds are highly selective for the 5-HT2B receptor. Oral administration of compound 15 (30 mg/kg) produced significant attenuation of visceral hypersensitivity in a rat model of irritable bowel syndrome (IBS). We expect this novel scaffold will serve as the foundation for the development of 5-HT2B antagonists for the treatment of IBS.
