68304-21-2 Usage
Description
8-Hydroxy-2-oxo-1,2-dihydro-5-quinolinecarboxaldehyde is an organic compound with the molecular formula C10H7NO3. It is a derivative of quinoline, which is a heterocyclic compound with a nitrogen atom in the ring structure. 8-Hydroxy-2-oxo-1,2-dihydro-5-quinolinecarboxaldehyde is characterized by its aldehyde group, which gives it reactivity and potential for further chemical modification.
Uses
Used in Pharmaceutical Industry:
8-Hydroxy-2-oxo-1,2-dihydro-5-quinolinecarboxaldehyde is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a key component in the development of new drugs, particularly those targeting specific receptors or enzymes in the body.
Used in Chemical Research:
8-Hydroxy-2-oxo-1,2-dihydro-5-quinolinecarboxaldehyde is also utilized in chemical research for studying the properties and reactivity of quinoline derivatives. It can be used to explore new synthetic pathways and develop novel chemical reactions that could lead to the creation of new molecules with potential applications in various fields.
Used in Metabolite Studies:
As a metabolite of procaterol hydrochloride (Meptin), a β2-adrenergic agonist used in the treatment of asthma, 8-Hydroxy-2-oxo-1,2-dihydro-5-quinolinecarboxaldehyde is relevant in the study of drug metabolism and pharmacokinetics. Understanding its role in the body can provide insights into the effectiveness and safety of procaterol hydrochloride as a treatment for asthma.
Check Digit Verification of cas no
The CAS Registry Mumber 68304-21-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,3,0 and 4 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 68304-21:
(7*6)+(6*8)+(5*3)+(4*0)+(3*4)+(2*2)+(1*1)=122
122 % 10 = 2
So 68304-21-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H7NO3/c12-5-6-1-3-8(13)10-7(6)2-4-9(14)11-10/h1-5,13H,(H,11,14)
68304-21-2Relevant articles and documents
Method for preparing 5-formyl-8-hydroxy-1, 3, 4-trihydroquinoline-2-ketone
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Paragraph 0035-0039, (2021/08/07)
The invention relates to a method for preparing 5-formyl-8-hydroxy-1, 3, 4-trihydroquinoline-2-ketone, and particularly relates to a method for preparing oxidative degradation impurity of procaterol. The method is easy to operate, high in yield and low in cost.
Kinetics of procaterol auto-oxidation in buffered acid solutions
Chen,Chafetz
, p. 703 - 706 (2007/10/02)
The kinetics of procaterol (1) degradaton in buffered acidic solutions (pH 4-6) was investigated using a HPLC procedure. The effect of temperature and ferric ions on the reaction rate was estimated. In acidic solutions, 1 undergoes pseudo first-order degradation with an induction period. The first-order rate constant for degradation increased and the induction period decreased with an increase in pH. Ferric ions catalyzed the degradation reaction and decreased the induction period. At pH 6, the activation energy of the reaction was 34.5 kcal/mol/deg. The results of this study indicate that 1 in solution is more stable at acidic pH, in the absence of heavy metal ions, and protected from air.
