68321-44-8 Usage
Description
1-(2'-tetrahydrothienyl) 5-fluorouracil is a chemical compound that combines the properties of 5-fluorouracil, a chemotherapy agent that inhibits cancer cell growth, with 2'-tetrahydrothienyl, a thymidylate synthase inhibitor. 1-(2'-tetrahydrothienyl) 5-fluorouracil targets an enzyme crucial for DNA synthesis and repair, thereby preventing the replication of cancer cells.
Uses
Used in Anticancer Applications:
1-(2'-tetrahydrothienyl) 5-fluorouracil is used as an anticancer agent for its potential to treat certain types of cancer, such as colorectal and gastrointestinal cancers. It works by inhibiting thymidylate synthase, an enzyme necessary for DNA synthesis and repair, which in turn stops cancer cells from replicating.
Used in Pharmaceutical Research:
1-(2'-tetrahydrothienyl) 5-fluorouracil is used as a research compound for exploring its therapeutic potential in oncology. Further studies are being conducted to understand its efficacy and possible side effects, with the aim of developing it into a viable treatment option for various cancers.
Check Digit Verification of cas no
The CAS Registry Mumber 68321-44-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,3,2 and 1 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 68321-44:
(7*6)+(6*8)+(5*3)+(4*2)+(3*1)+(2*4)+(1*4)=128
128 % 10 = 8
So 68321-44-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H9FN2O2S/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12/h4,6H,1-3H2,(H,10,12,13)
68321-44-8Relevant articles and documents
Synthesis and Antitumor Activity of a Series of Ftorafur Analogues: The Effect of Varying Electronegativity at the 1'-Position
Holshouser, Mark H.,Shipp, Annette M.,Ferguson, Paul W.
, p. 242 - 245 (2007/10/02)
To test the effect of changes in electronegativity within the alicyclic N-1 substituent of substituted 5-fluorouracil analogues on cytotoxic activity, a series of derivatives of ftorafur, 1-(2'-tetrahydrofuranyl)-5-fluorouracil, was synthesized and tested for antitumor activity in the P388 lymphocytic leukemia screen and cytotoxic activity in the L1210 cell culture screen.Two compounds of N-1 substituent with high electronegativity, the 2'-tetrahydrothiophene 1'-oxide and the 2'-tetrahydrothiophene 1',1'-dioxide derivatives, demonstrated the highest in vitro L1210 cell inhibition (84.5percent and 92.0percent, respectively).Furthermore, against P388 lymphocytic leukemia in vivo, the 2'-tetrahydrothiophene 1'-oxide derivative showed significant activity (T/C = 143).Other compounds of similar or lower electronegativity within the N-1 cyclic substituent were inactive against P388 lymphocytic leukemia and less active against L1210 cells.
