683234-73-3

Basic information

• Product Name: 2-Propenoic acid, 2-[(4-chlorobenzoyl)amino]-3-(dimethylamino)-, methyl ester, (2Z)-
• CAS NO: 683234-73-3
• Molecular Formula: C13H15ClN2O3
• Molecular Weight: 282.727
• Mol File: 683234-73-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 2-[(4-chlorobenzoyl)amino]-3-(dimethylamino)-, methyl ester, (2Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 2-[(4-chlorobenzoyl)amino]-3-(dimethylamino)-, methyl ester, (2Z)-(683234-73-3)
• EPA Substance Registry System: 2-Propenoic acid, 2-[(4-chlorobenzoyl)amino]-3-(dimethylamino)-, methyl ester, (2Z)-(683234-73-3)

Safety Data

• Hazardous Substances Data: 683234-73-3(Hazardous Substances Data)

Upstream product

• 13450-77-6 4-chlorohippuric acid 
• 67-56-1 methanol 

Downstream Products

• 209742-75-6 2-(4-Chloro-phenyl)-4-[1-hydroxy-meth-(Z)-ylidene]-4H-oxazol-5-one 

Relevant articles and documents

Unusual reactions of 2-aryl-4-(N,N-dimethylaminomethylene)-2-oxazolin5-ones with O-nucleophiles: Synthesis of 2-aryl-4-hydi oxymethylene- 2-oxazolin-5-ones

The reactions of 2-aryl-4-(N,N-dimethyIaminomethylene)-2- oxazolin-5-ones 2 with aqueous or ethanolic KOH and sodium ethoxide lead to the formation of 2-aryl-4-hydroxymethylene-2-oxazolin-5ones 4, 1,5-bond remaining unaffected. However, the reactions of 2 with aqueous or methanolic KOH afford methyl 2-acylamino-3-dimethylaminopropenoates 9 along with 4. These observations are explained by the hard-soft acid-base (HSAB) principle. Further, compounds 9 on treatment with POCl3 in pyridine and ethanolic KOH give the corresponding cyclized products 2 and 4, respectively.