683274-51-3 Usage
Description
1,4-DIAZEPAN-1-YL(2-THIENYL)METHANONE is a chemical compound with the molecular formula C13H12N2OS, belonging to the benzodiazepine class. It features a seven-membered diazepine ring fused with a thienyl group and a ketone functional group, exhibiting central nervous system depressant effects. 1,4-DIAZEPAN-1-YL(2-THIENYL)METHANONE is utilized in research for its potential as a therapeutic agent for anxiety-related disorders and as a precursor in the synthesis of related benzodiazepine derivatives. Its pharmacological and toxicological properties are currently under investigation.
Uses
Used in Pharmaceutical Research:
1,4-DIAZEPAN-1-YL(2-THIENYL)METHANONE is used as a potential therapeutic agent for anxiety-related disorders due to its central nervous system depressant effects.
Used in Chemical Synthesis:
1,4-DIAZEPAN-1-YL(2-THIENYL)METHANONE is used as a precursor in the synthesis of related benzodiazepine derivatives, contributing to the development of new psychoactive drugs with potential anxiolytic, sedative, and muscle-relaxant properties.
Check Digit Verification of cas no
The CAS Registry Mumber 683274-51-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,8,3,2,7 and 4 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 683274-51:
(8*6)+(7*8)+(6*3)+(5*2)+(4*7)+(3*4)+(2*5)+(1*1)=183
183 % 10 = 3
So 683274-51-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H14N2OS/c13-10(9-3-1-8-14-9)12-6-2-4-11-5-7-12/h1,3,8,11H,2,4-7H2
683274-51-3Relevant articles and documents
Synthesis, Cytotoxicity Evaluation, and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands
Zampieri, Daniele,Fortuna, Sara,Calabretti, Antonella,Romano, Maurizio,Menegazzi, Renzo,Schepmann, Dirk,Wünsch, Bernhard,Mamolo, Maria Grazia
, p. 651 - 656 (2020)
Among several potential applications, sigma receptor ligands can be used as antipsychotics, antiamnesics, and against other neurodegenerative disorders as well as neuroprotective agents. We present herein a new series of diazepane-containing derivatives as σR ligands obtained by a conformational expansion approach of our previously synthesized piperidine-based compounds. The best results were reached by benzofurane 2c, 3c and quinoline 2d, 3d-substituted diazepane derivatives, which showed the highest σR affinity. The cytotoxic activities of synthesized compounds were evaluated against two cancer cell lines, and the results indicated that none of the compounds induced significant toxicity in these cells. We also evaluated the antioxidant activity by radical scavenging capacity of our best compounds on ABTS and H2O2. The results obtained reveal that our new derivatives possess an excellent antioxidant profile and could be protective for the cells. Overall, the benzofurane derivative 2c due to its strong interaction with the active site of the receptor, as confirmed by molecular dynamic simulations, emerged as the optimum compound with high σ1R affinity, low cytotoxicity, and a potent antioxidant activity.