68337-08-6

Basic information

• Product Name: 1H-Imidazole, 1-(4-methoxyphenyl)-2-methyl-
• CAS NO: 68337-08-6
• Molecular Formula: C11H12N2O
• Molecular Weight: 188.229
• Mol File: 68337-08-6.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 1H-Imidazole, 1-(4-methoxyphenyl)-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole, 1-(4-methoxyphenyl)-2-methyl-(68337-08-6)
• EPA Substance Registry System: 1H-Imidazole, 1-(4-methoxyphenyl)-2-methyl-(68337-08-6)

Safety Data

• Hazardous Substances Data: 68337-08-6(Hazardous Substances Data)

Upstream product

• 693-98-1 2-methylimidazole 
• 5720-07-0 4-methoxyphenylboronic acid 
• 623-12-1 4-chloromethoxybenzene 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 696-62-8 para-iodoanisole 

Downstream Products

• 81376-54-7 1-(4-hydroxyphenyl)-2-methylimidazole 
• 1428368-08-4 7-methoxy-1-methyl-4,5-diphenylimidazo[1,5-a]quinoline 

Relevant articles and documents

Intercalation of copper salt to montmorillonite K-10 and its application as a reusable catalyst for Chan–Lam cross-coupling reaction

A simple and efficient catalytic system has been developed by adsorption of copper salt in the interlayers of montmorillonite K-10. The catalytic system impressively exercises the green chemistry perspective leading to effortless recovery and recyclabilit

Identification of N-Arylated NH125 Analogues as Rapid Eradicating Agents against MRSA Persister Cells and Potent Biofilm Killers of Gram-Positive Pathogens

Bacterial biofilms housing dormant persister cells are innately tolerant to antibiotics and disinfectants, yet several membrane-active agents are known to eradicate tolerant bacterial cells. NH125, a membrane-active persister killer and starting point for development, led to the identification of two N-arylated analogues (1 and 2) that displayed improved biofilm eradication potencies compared to the parent compound and rapid persister-cell-killing activities in stationary cultures of methicillin-resistant Staphylococcus aureus (MRSA). We found 1 and 2 to be superior to other membrane-active agents in biofilm eradication assays, with 1 demonstrating minimum biofilm eradication concentrations (MBEC) of 23.5, 11.7, and 2.35 μm against MRSA, methicillin-resistant Staphylococcus epidermidis (MRSE), and vancomycin-resistant Enterococcus faecium (VRE) biofilms, respectively. We tested our panel of membrane-active agents against MRSA stationary cultures and found 1 to rapidly eradicate MRSA stationary cells by 4 log units (99.99 %) in 30 min. The potent biofilm eradication and rapid persister-cell-killing activities exhibited by N-arylated NH125 analogues could have significant impact in addressing biofilm-associated problems.

Copper Oxide Nanoparticles as a Mild and Efficient Catalyst for N-Arylation of Imidazole and Aniline with Boronic Acids at Room Temperature

The present work describes the excellent catalytic activity of copper(II) oxide nanoparticles (NPs) towards N-arylation of aniline and imidazole at room temperature. The copper(II)oxide NPs were synthesized by a thermal refluxing technique and characterized by FT-IR spectroscopy; powder XRD, SEM, EDX, TEM, TGA, XPS, BET surface area analysis, and particle size analysis. The size of the NPs was found to be around 12 nm having a surface area of 164.180 m 2 g -1.The catalytic system was also found to be recyclable and could be reused in subsequent catalytic runs without a significant loss of activity.