68415-05-4

Basic information

• Product Name: 4-Morpholineacetonitrile, a-(3,4,5-trimethoxyphenyl)-
• CAS NO: 68415-05-4
• Molecular Formula: C15H20N2O4
• Molecular Weight: 292.335
• Mol File: 68415-05-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-Morpholineacetonitrile, a-(3,4,5-trimethoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Morpholineacetonitrile, a-(3,4,5-trimethoxyphenyl)-(68415-05-4)
• EPA Substance Registry System: 4-Morpholineacetonitrile, a-(3,4,5-trimethoxyphenyl)-(68415-05-4)

Safety Data

• Hazardous Substances Data: 68415-05-4(Hazardous Substances Data)

Upstream product

• 773837-37-9 sodium cyanide 
• 10024-89-2 morpholin hydrochloride 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 110-91-8 morpholine 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 151-50-8 potassium cyanide 

Downstream Products

• 134454-88-9 1-(3',4',5'-trimethoxyphenyl)-1,2-dihydro-4,5-methylenedioxybenzocyclobuten-1-ol 
• 160869-33-0 (5R,5aR,8aR)-5-(3,4,5-Trimethoxy-phenyl)-5,5a,8a,9-tetrahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole-6,8-dione 
• 160823-61-0 (5R,6R,7R)-5-(3,4,5-Trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6,7-dicarboxylic acid 
• 160823-58-5 (5R,6S,7R)-5-Hydroxy-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6,7-dicarboxylic acid bis-((S)-methoxycarbonyl-phenyl-methyl) ester 
• 160823-59-6 (5R,6R,7R)-5-(3,4,5-Trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6,7-dicarboxylic acid bis-((S)-methoxycarbonyl-phenyl-methyl) ester 
• 477-51-0 deoxypodophyllotoxin 
• 176972-44-4 3-(3,4,5-trimethoxyphenyl)-1H-isochromen-1-one 
• 134454-84-5 1-(3,4,5-trimethoxyphenyl)-2-(2'-iodo-4',5'-methylenedioxyphenyl)ethanone 
• 134454-92-5 1-(3',4',5'-trimethoxyphenyl)-4,5-methylenedioxybenzocyclobutene 
• 100613-36-3 1-(3,4,5-trimethoxyphenyl)butane-1,3-dione 

Relevant articles and documents

Aged red wine pigments as a source of inspiration for organic synthesis - The cases of the color-stable pyranoflavylium and flavylium-(4→8)-flavan chromophores

Two flavylium-based chromophores peculiar to aged red wine pigments are investigated from a synthetic viewpoint. The condensation between easy-to-prepare 5-hydroxy-4-methylflavylium salts and aldehydes, giving birth to color-stable pyranoflavylium pigments, further proves efficient and wide in scope. A set of some twenty structurally-related flavylium-based pigments has been prepared and structure:color relationships are discussed. Furthermore, the synthesis of the flavylium-(4→8)-flavan chromophore is achieved via a novel three-step sequence. The elaborated sequence starts with an iodine-magnesium exchange from an 8-iodinated flavan, thus generating a magnesiated species that then smoothly reacts with a flavone to furnish an adduct, that finally leads to the expected chromophore via dehydration.

An asymmetric synthesis of (-)-deoxypodophyllotoxin

A Diels-Alder cycloaddition between the fumarate of methyl (S)-mandelate (22) and α-hydroxy-α-aryl-o-quinodimethane 21 produces an endo cycloadduct (23) in 58% yield. The preparation of the precursor to o-quinodimethane 21 and the conversion of cycloadduct 23 to optically pure (-)-deoxypodophyllotoxin (1) is described.