68420-92-8

Basic information

• Product Name: 6-Methyl-8-nitroquinoline
• Synonyms: 6-Methyl-8-nitroquinoline
• CAS NO: 68420-92-8
• Molecular Formula: C₁₀H₈N₂O₂
• Molecular Weight: 188.1827
• Mol File: 68420-92-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 344.6°Cat760mmHg
• Flash Point: 162.2°C
• Appearance: /
• Density: 1.298g/cm³
• Vapor Pressure: 0.00013mmHg at 25°C
• Refractive Index: 1.661
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-Methyl-8-nitroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methyl-8-nitroquinoline(68420-92-8)
• EPA Substance Registry System: 6-Methyl-8-nitroquinoline(68420-92-8)

Safety Data

• Hazardous Substances Data: 68420-92-8(Hazardous Substances Data)

Usage

Description

6-Methyl-8-nitroquinoline, an organic compound with the molecular formula C10H8N2O2, is a yellow crystalline solid that is insoluble in water but soluble in organic solvents. It is primarily used as an intermediate in the manufacturing of various pharmaceuticals and agrochemicals.

Uses

Used in Pharmaceutical Industry:
6-Methyl-8-nitroquinoline is used as an intermediate for the synthesis of various pharmaceuticals, contributing to the development of important products in the industry.
Used in Agrochemical Industry:
6-Methyl-8-nitroquinoline is used as an intermediate for the production of agrochemicals, playing a crucial role in the development of products in the agricultural sector.
Used in Antibiotic Development:
6-Methyl-8-nitroquinoline is used as a compound with antimicrobial properties, aiding in the development of antibiotics to combat various infections.
Used in Pesticide Development:
6-Methyl-8-nitroquinoline is used as a compound with insecticidal properties, contributing to the development of pesticides for controlling pests in agriculture.
Note: The information provided does not specify the exact applications or reasons for the use of 6-Methyl-8-nitroquinoline in different industries. The uses listed above are inferred from its properties and general applications in the pharmaceutical and agrochemical industries.

InChI:InChI=1/C10H8N2O2/c1-7-5-8-3-2-4-11-10(8)9(6-7)12(13)14/h2-6H,1H3

Upstream product

• 56-81-5 glycerol 
• 89-62-3 4-methyl-2-nitroaniline 
• 107-02-8 acrolein 
• 68527-67-3 6-bromo-8-nitroquinoline 
• 823-96-1 Trimethylboroxine 
• 875-51-4 4-Bromo-2-nitroaniline 

Downstream Products

• 68420-93-9 8-amino-6-methylquinoline 
• 3002-78-6 5-methyl-1,10-phenanthroline 
• 20984-33-2 6-Methyl-8-hydroxyquinoline 

Relevant articles and documents

Synthesis and in vitro evaluation of novel 8-aminoquinoline-pyrazolopyrimidine hybrids as potent antimalarial agents

In the search of novel chemotherapeutic agents for emerging drug resistant parasites, the hybridization approaches have successfully emerged as an efficient tool in malarial chemotherapy. Herein, a rational design and synthesis of novel 8-aminoquinoline and pyrazolopyrimidine hybrids and their antimalarial activity against wild type Plasmodium falciparum (Pf-NF54) and resistant strain (Pf-K1) is reported. The medicinal chemistry approach to expand the scope of this series resulted in an identification of potent compounds with nanomolar potency (best IC50 5-10 nM). Systematic structure activity relationship (SAR) studies revealed that pyrazolopyrimidine and 8-aminoquinoline ring are essential for achieving good P. falciparum potency. The docking study revealed that the compound 6 can retain some of the critical interactions within pfDHODH drug target.

HETEROARYL COMPOUNDS AS CXCR4 INHIBITORS, COMPOSITION AND METHOD USING THE SAME

The present disclosure provides heteroaryl compounds of Formula (I), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to the CXCR4 pathway.

TRIPLE SUBSTITUTED PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES OR CONDITIONS, OR CANCER

The present invention relates to a new family of triple substituted phenantroline derivatives of formula (I), which are useful for the treatment or profilaxis of a neurodegenerative or haematological disease or condition or cancer, their use as a medicament, especially for treating a neurodegenerative or haematological disease or condition or cancer, and a pharmaceutical composition comprising the compounds.