68453-37-2

Basic information

• Product Name: METHYL 4-(PIPERIDIN-1-YLMETHYL)BENZOATE
• Synonyms: METHYL 4-(PIPERIDIN-1-YLMETHYL)BENZOATE;Methyl 4-(1-piperidinylmethyl)benzoate
• CAS NO: 68453-37-2
• Molecular Formula: C₁₄H₁₉NO₂
• Molecular Weight: 233.31
• Mol File: 68453-37-2.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 330.7 °C at 760 mmHg
• Flash Point: 118.9 °C
• Appearance: /
• Density: 1.091 g/cm³
• Vapor Pressure: 0.000164mmHg at 25°C
• Refractive Index: 1.544
• PKA: 8.47±0.10(Predicted)
• CAS DataBase Reference: METHYL 4-(PIPERIDIN-1-YLMETHYL)BENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-(PIPERIDIN-1-YLMETHYL)BENZOATE(68453-37-2)
• EPA Substance Registry System: METHYL 4-(PIPERIDIN-1-YLMETHYL)BENZOATE(68453-37-2)

Safety Data

• Hazardous Substances Data: 68453-37-2(Hazardous Substances Data)

Usage

General Description

Methyl 4-(piperidin-1-ylmethyl)benzoate is a chemical compound with the molecular formula C16H19NO2. It is a benzamide derivative that is commonly used in the synthesis of various pharmaceutical and organic compounds. METHYL 4-(PIPERIDIN-1-YLMETHYL)BENZOATE is often utilized as an intermediate in the production of other chemical compounds and drugs. It has a piperidine group attached to a benzoate group, making it valuable in the development of new medicinal products. Additionally, methyl 4-(piperidin-1-ylmethyl)benzoate has also shown potential as an inhibitor of certain enzymes, making it of interest in biochemical and pharmaceutical research.

InChI:InChI=1/C14H19NO2/c1-17-14(16)13-7-5-12(6-8-13)11-15-9-3-2-4-10-15/h5-8H,2-4,9-11H2,1H3

Upstream product

• 67-56-1 methanol 
• 110-89-4 piperidine 
• 6757-32-0 4-(piperidine-1-carbonyl)benzoic acid methyl ester 
• 1571-08-0 methyl 4-formylbenzoate 
• 660-88-8 5-aminopentanoic acid 
• 619-66-9 4-Carboxybenzaldehyde 
• 1314659-42-1 4-formyl-N,N-bis(pyridin-2-ylmethyl)benzamide 
• 1314659-61-4 4-(piperidin-1-ylmethyl)-N,N-bis(pyridin-2-ylmethyl)benzamide 
• 34040-64-7 p-methyloxycarbonylbenzyl chloride 
• 2417-72-3 Methyl 4-(bromomethyl)benzoate 

Downstream Products

• 159691-33-5 4-(piperidin-1-ylmethyl)benzoic acid 
• 1350648-07-5 2,3-diamino-N₂-(4-(piperidin-1-ylmethyl)benzyl)quinoxaline 
• 1350648-02-0 N-(3-aminoquinoxalin-2-yl)-4-(piperidin-1-ylmethyl)benzamide 
• 91271-62-4 (4-(piperidin-1-ylmethyl)phenyl)methanol 
• 768320-30-5 4-(piperidin-1-ylmethyl)benzoyl chloride 

Relevant articles and documents

Hydrosilylative reduction of primary amides to primary amines catalyzed by a terminal [Ni-OH] complex

A terminal [Ni-OH] complex1, supported by triflamide-functionalized NHC ligands, catalyzes the hydrosilylative reduction of a range of primary amides into primary amines in good to excellent yields under base-free conditions with key functional group tolerance. Catalyst1is also effective for the reduction of a variety of tertiary and secondary amides. In contrast to literature reports, the reactivity of1towards amide reduction follows an inverse trend,i.e., 1° amide > 3° amide > 2° amide. The reaction does not follow a usual dehydration pathway.

Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections

The recent Ebola epidemics in West Africa underscore the great need for effective and practical therapies for future Ebola virus outbreaks. We have discovered a new series of remarkably potent small molecule inhibitors of Ebola virus entry. These 4-(aminomethyl)benzamide-based inhibitors are also effective against Marburg virus. Synthetic routes to these compounds allowed for the preparation of a wide variety of structures, including a conformationally restrained subset of indolines (compounds 41-50). Compounds 20, 23, 32, 33, and 35 are superior inhibitors of Ebola (Mayinga) and Marburg (Angola) infectious viruses. Representative compounds (20, 32, and 35) have shown good metabolic stability in plasma and liver microsomes (rat and human), and 32 did not inhibit CYP3A4 nor CYP2C9. These 4-(aminomethyl)benzamides are suitable for further optimization as inhibitors of filovirus entry, with the potential to be developed as therapeutic agents for the treatment and control of Ebola virus infections.

BENZAMIDE DERIVATIVES FOR INHIBITING ENDOPLASMIC RETICULUM (ER) STRESS

Novel 3-(N-piperidinyl)methyl benzamide derivatives are disclosed. The compounds can be used in treating diseases and conditions which are associated with abnormal cell function related to endoplasmic reticulum (ER) stress. For example, the compounds can