685-69-8 Usage
General Description
ETHYL-2,4,4,4-TETRAFLUOROACETOACETATE, also known as ETFA or ethyl tetrafluoroacetoacetate, is a chemical compound with the molecular formula C6H5F4O3. It is a colorless, clear liquid that is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. ETFA is also used as a building block in the production of various fluorinated compounds, such as fluorinated amino acids and peptides. It is a highly reactive compound that requires careful handling due to its potential for exothermic reactions, and it is important to use appropriate safety measures when working with ETFA.
Check Digit Verification of cas no
The CAS Registry Mumber 685-69-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,8 and 5 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 685-69:
(5*6)+(4*8)+(3*5)+(2*6)+(1*9)=98
98 % 10 = 8
So 685-69-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H6F4O3/c1-2-5(7,4(12)13)3(11)6(8,9)10/h2H2,1H3,(H,12,13)/p-1
685-69-8Relevant articles and documents
Tetrafluorine-containing ketones and acetoacetates: Synthesis and mechanistic study
Tsai, Hou-Jen,Hsieh, Chi-Wei
, p. 749 - 757 (2008/03/11)
Addition of trimethylsilyl trifluoroacetate to the carbanions of α-fluorobenzyl-phosphonate (3) or diisopropyl(fluorocarbethoxymethyl) phosphonate (9) formed the corresponding intermediates [CF3C(O)CFPh] -Li+ (10) and [CF3C(O)CFCO2Et] -Li+ (11), respectively. Subsequent protonation, alkylation or allylation of 10 and 11 afforded trifluoromethyl fluorobenzyl ketones 12 and ethyl 2,4,4,4-tetra-fluoroacetoacetates 13. Based on the results obtained, a plausible mechanism was proposed.
