685540-79-8

Basic information

• Product Name: 1H-1,2,4-Triazol-3-amine, 5-[[[4-(1,1-dimethylethyl)phenyl]methyl]thio]-
• CAS NO: 685540-79-8
• Molecular Formula: C13H18N4S
• Molecular Weight: 262.379
• Mol File: 685540-79-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-1,2,4-Triazol-3-amine, 5-[[[4-(1,1-dimethylethyl)phenyl]methyl]thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,2,4-Triazol-3-amine, 5-[[[4-(1,1-dimethylethyl)phenyl]methyl]thio]-(685540-79-8)
• EPA Substance Registry System: 1H-1,2,4-Triazol-3-amine, 5-[[[4-(1,1-dimethylethyl)phenyl]methyl]thio]-(685540-79-8)

Safety Data

• Hazardous Substances Data: 685540-79-8(Hazardous Substances Data)

Upstream product

• 18880-00-7 1-(bromomethyl)-4-(1,1-dimethylethyl)benzene 
• 118025-46-0 3-amino-1H-1,2,4-triazole-5-thiol 
• 16691-43-3 5-amino-3-mercapto-4H-[1,2,4]triazole 
• 19692-45-6 4-tert-butylbenzyl chloride 

Relevant articles and documents

Structure based designing of triazolopyrimidone-based reversible inhibitors for kinases involved in NSCLC

Secondary acquired mutant EGFR (L858R-T790M)overexpressed NSCLC forms one of the prevalent form of resistant NSCLC. Another subset of resistant NSCLC includes amplified cMET in mutant EGFR derived tumours. Thus, in continuation to our previous work on the

Discovery of inhibitors of Burkholderia pseudomallei methionine aminopeptidase with antibacterial activity

Evaluation of a series of MetAP inhibitors in an in vitro enzyme activity assay led to the first identification of potent molecules that show significant growth inhibition against Burkholderia pseudomallei. Nitroxoline analogues show excellent inhibition potency in the BpMetAP1 enzyme activity assay with the lowest IC50 of 30 nM and inhibit the growth of B. pseudomallei and B. thailandensis at concentrations ≥31 μM.