685542-10-3

Basic information

• Product Name: Benzenesulfonic acid, 4-(trifluoromethoxy)-, hydrazide
• CAS NO: 685542-10-3
• Molecular Formula: C7H7F3N2O3S
• Molecular Weight: 256.205
• Mol File: 685542-10-3.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Benzenesulfonic acid, 4-(trifluoromethoxy)-, hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonic acid, 4-(trifluoromethoxy)-, hydrazide(685542-10-3)
• EPA Substance Registry System: Benzenesulfonic acid, 4-(trifluoromethoxy)-, hydrazide(685542-10-3)

Safety Data

• Hazardous Substances Data: 685542-10-3(Hazardous Substances Data)

Upstream product

• 94108-56-2 4-(trifluoro-methoxy)benzene-1-sulfonyl chloride 

Downstream Products

• 164171-92-0 1-(phenylethynyl)-4-(trifluoromethoxy)benzene 

Relevant articles and documents

Dual Roles of Rongalite: Reductive Coupling Reaction to Construct Thiosulfonates Using Sulfonyl Hydrazides

A tunable and practical transformation of structurally diverse sulfonyl hydrazides into thiosulfonates in the presence of Rongalite (NaHSO 2·CH 2O) was developed. Transition-metal-free conditions, operational simplicity, and readily available reagents are the striking features of this protocol. It is the first example for the synthesis of thiosulfonates using sulfonyl hydrazides with the assistance of reductant. Additionally, the mechanistic studies revealed that this transformation probably undergoes via a reducing-coupling pathway.

NaHSO3-Mediated Direct Synthesis of Sulfinic Esters from Sulfonyl Hydrazides under Transition-Metal-Free Conditions

We have developed a protocol for the NaHSO3-promoted esterification of sulfonyl hydrazides with alcohols for the synthesis of sulfinic esters. Various sulfonyl hydrazides could be converted to the corresponding sulfinic esters in good to high yields. The merits of this protocol include mild transition-metal-free reaction conditions, an inexpensive and available reagent, and operational simplicity. Controlled experiments reveal that this transformation probably undergoes via a radical pathway. (Figure presented.).

TBAB-catalyzed 1,6-conjugate sulfonylation of paraquinone methides: A highly efficient approach to unsymmetrical gem-diarylmethyl sulfones in water ?

A highly efficient sulfonylation of para-quinone methides with sulfonyl hydrazines in water has been developed on the basis of the mode involving a tetrabutyl ammonium bromide (TBAB)-promoted sulfa-1,6-conjugated addition pathway. This reaction provides a green and sustainable method to synthesize various unsymmetrical diarylmethyl sulfones, showing good functional group tolerance, scalability, and regioselectivity. Further transformation of the resulting diarylmethyl sulfones provides an efficient route to some functionalized molecules.