68630-75-1 Usage
Description
Buserelin, also known as Buserelin Acetate, is a potent analog of the hypothalamic hormone luteinizing hormone-releasing hormone (LH-RH). It is a synthetic nonapeptide agonist that functions as an antineoplastic (hormonal) agent. Buserelin is used to treat hormone-responsive cancers such as prostate and breast cancer. Chronic administration of higher doses of Buserelin desensitizes the pituitary, leading to a decreased production of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and eventually sex steroids (testosterone in males and estradiol in females). It is a white solid and has been investigated for various applications, including endometriosis, leiomyoma, precocious puberty, advanced breast cancer, and infertility.
Uses
Used in Cancer Treatment:
Buserelin is used as a gonadotropin-releasing hormone agonist for the treatment of hormone-responsive cancers such as prostate and breast cancer. It modulates the hormonal balance by decreasing the production of sex steroids, which can help in controlling the growth of cancer cells that rely on these hormones for their proliferation.
Used in Medical Castration:
Buserelin is used as a medical castration agent in the treatment of advanced prostate cancer. By desensitizing the pituitary gland and reducing the production of sex steroids, Buserelin helps in controlling the progression of prostate cancer.
Used in Endometriosis Treatment:
Buserelin is used as a hormonal treatment for endometriosis, a condition where the tissue that lines the uterus grows outside the uterus. It helps in reducing the symptoms and improving the quality of life for patients suffering from this condition.
Used in Leiomyoma Treatment:
Buserelin is used as a treatment option for leiomyoma, a type of benign tumor that develops in the uterus. By regulating the hormonal balance, it can help in reducing the size of the tumor and alleviating the associated symptoms.
Used in Precocious Puberty Treatment:
Buserelin is used as a treatment for precocious puberty, a condition where children experience the onset of puberty at an unusually early age. It helps in delaying the onset of puberty by regulating the hormonal balance.
Used in Advanced Breast Cancer Treatment:
Buserelin is used as a treatment for advanced breast cancer, particularly in cases where the cancer is hormone-responsive. It helps in controlling the growth of cancer cells by modulating the hormonal balance.
Used in Infertility Treatment:
Buserelin is used as a treatment option for infertility, particularly in cases where hormonal imbalances are contributing to the issue. It helps in regulating the hormonal balance, which can improve the chances of conception.
Originator
Hoechst AG (W. Germany)
Biochem/physiol Actions
Buserelin is an LH-RH agonist.
Check Digit Verification of cas no
The CAS Registry Mumber 68630-75-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,6,3 and 0 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 68630-75:
(7*6)+(6*8)+(5*6)+(4*3)+(3*0)+(2*7)+(1*5)=151
151 % 10 = 1
So 68630-75-1 is a valid CAS Registry Number.
InChI:InChI=1/C60H86N16O13.C2H4O2/c1-7-64-57(87)48-15-11-23-76(48)58(88)41(14-10-22-65-59(61)62)69-51(81)42(24-33(2)3)70-56(86)47(31-89-60(4,5)6)75-52(82)43(25-34-16-18-37(78)19-17-34)71-55(85)46(30-77)74-53(83)44(26-35-28-66-39-13-9-8-12-38(35)39)72-54(84)45(27-36-29-63-32-67-36)73-50(80)40-20-21-49(79)68-40;1-2(3)4/h8-9,12-13,16-19,28-29,32-33,40-48,66,77-78H,7,10-11,14-15,20-27,30-31H2,1-6H3,(H,63,67)(H,64,87)(H,68,79)(H,69,81)(H,70,86)(H,71,85)(H,72,84)(H,73,80)(H,74,83)(H,75,82)(H4,61,62,65);1H3,(H,3,4)/t40-,41-,42-,43-,44-,45-,46-,47+,48-;/m0./s1
