687-51-4

Basic information

• Product Name: H-LEU-NH2
• Synonyms: leucinamide;H-LEU-NH2;LEUCINE-NH2;L-LEUCINE AMIDE;(S)-2-amino-4-methylvaleramide;(S)-2-Amino-4-methylpentanamide;L-Leu-NH2;(2S)-2-amino-4-methylpentanamide
• CAS NO: 687-51-4
• Molecular Formula: C₆H₁₄N₂O
• Molecular Weight: 130.19
• EINECS: 211-696-2
• Mol File: 687-51-4.mol
• Article Data: 21

Chemical Properties

• Melting Point: 84-85 °C(Solv: benzene (71-43-2); ethanol (64-17-5)(10:1))
• Boiling Point: 250.9±23.0 °C(Predicted)
• Appearance: /
• Density: 0.980±0.06 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 16.08±0.50(Predicted)
• CAS DataBase Reference: H-LEU-NH2(CAS DataBase Reference)
• NIST Chemistry Reference: H-LEU-NH2(687-51-4)
• EPA Substance Registry System: H-LEU-NH2(687-51-4)

Safety Data

• Hazardous Substances Data: 687-51-4(Hazardous Substances Data)

Usage

Description

H-LEU-NH2, also known as N-amino-L-leucine, is an amino acid amide derived from L-leucine, where the carboxy OH group is replaced by an NH2 group. It appears as a white crystalline powder and is a significant component in various biological processes.

Uses

Used in Pharmaceutical Industry:
H-LEU-NH2 is used as an active pharmaceutical ingredient for its potential role in modulating various biological pathways. Its unique structure allows it to interact with specific targets, making it a promising candidate for the development of new drugs.
Used in Research and Development:
In the field of research, H-LEU-NH2 is utilized as a key compound for studying the structure and function of proteins, as well as for understanding the mechanisms of various diseases. Its unique properties enable scientists to investigate its potential applications in therapeutic strategies.
Used in Drug Design and Synthesis:
H-LEU-NH2 serves as a valuable building block in the design and synthesis of novel drugs. Its unique structure can be incorporated into drug molecules to enhance their efficacy, selectivity, and pharmacokinetic properties.
Used in Nutritional Supplements:
As an amino acid amide, H-LEU-NH2 may be used as an additive in the nutritional supplement industry to support muscle growth, recovery, and overall health. Its specific properties could potentially offer benefits in sports nutrition and health products.
Used in Cosmetics Industry:
In the cosmetics industry, H-LEU-NH2 could be employed for its potential benefits in skin care products, such as promoting skin health and improving the appearance of the skin. Its unique properties may contribute to the development of innovative cosmetic formulations.

InChI:InChI=1/C6H14N2O/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H2,8,9)/t5-/m0/s1

Upstream product

• 70533-96-9 N-tert-butoxycarbonyl-(L)-leucinamide 
• 3350-19-4 (tert-butoxycarbonyl)-L-leucine p-nitrobenzylester 
• 869-19-2 Glycyl-L-leucine 
• 7664-41-7 ammonia 
• 13079-20-4 2-Amino-4-methyl-pentanoic acid amide 
• 60117-24-0 H-Tyr-Gly-Gly-Phe-Leu-NH₂ 
• 106827-71-8 Trt-L-Hse(Trt)-L-Leu-NH₂ 
• 65356-77-6 N-acetyl-L-triptophanyl-L-leucine amide 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 4801-79-0 N-benzyloxycarbonyl-L-leucinamide 
• 26400-33-9 N-(3-<2-furyl>acryloyl)-Gly-LeuNH2 
• 61-90-5 L-leucine 
• 2666-93-5 (S)-Leu-OMe 
• 35661-60-0 Fmoc-Leu-OH 

Downstream Products

• 17193-48-5 Z-(β-O-Bz-Asp)-Leu-NH2 
• 7535-72-0 (N-carboxybenzylglycinyl)leucinamide 
• 17331-87-2 Z-L-Ser-L-Leu-NH₂ 
• 126028-17-9 BocTyrLeuNH₂ 
• 69193-13-1 Cbz-L-Phe-L-Leu-NH₂ 
• 219309-96-3 C₂₆H₃₄N₄O₄S₂ 
• 75286-46-3 amide of N-t-butyloxycarbonylglycylglycyl-L-phenylalanyl-L-leucine 
• 500767-13-5 (2S,5S,6S)-3-aza-6-[(tert-butyloxycarbonyl)amino]-2-isobutyl-5-hydroxy-7-phenylheptanoyl amide 
• 74392-85-1 Boc Tyr D_.Ala Gly Phe Leu NH₂ 
• 724733-53-3 (3S,4S)-4-azido-5-benzyloxy-3-hydroxypentanoic acid [(S)-1-((S)-1-carbamoyl-3-methylbutylcarbamoyl)ethyl]amide 

Relevant articles and documents

Enzymatic stability of myostatin inhibitory 16-mer peptides

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HEMIAMINAL-TAG FOR PROTEIN LABELING AND PURIFICATION

The invention pertains to the synthesis, isolation, and characterization of hemiaminal for selective labeling of peptides, proteins, antibodies, and organic fragments with -C(=0) CH2NH2 and derivatives with -CH2NH2 group over -C(=0) CHRNH2 group (where R≠H). The invention also pertains to the method of single-site immobilization of proteins through N-terminus Gly on solid phase. The invention includes late-stage tagging of N-terminus Gly with an affinity tag, 19F NMR probe, and a fluorophore and a method for metal-free protein purification and isolation of analytically pure proteins.

SYNTHESIS OF ARYL CYCLOHEXANE CARBOXAMIDE DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS

Synthesis methods to produce a series of carboxamides built off of an (S)-2-amino acid backbone or an (R)-2-amino acid backbone, depending upon the desired diastereomer of the end product.