68709-71-7

Basic information

• Product Name: Carbamic acid, [3-bromo-2-oxo-1-(phenylmethyl)propyl]-, 1,1-dimethylethyl ester, (S)-
• CAS NO: 68709-71-7
• Molecular Formula: C15H20BrNO3
• Molecular Weight: 342.233
• Mol File: 68709-71-7.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [3-bromo-2-oxo-1-(phenylmethyl)propyl]-, 1,1-dimethylethyl ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [3-bromo-2-oxo-1-(phenylmethyl)propyl]-, 1,1-dimethylethyl ester, (S)-(68709-71-7)
• EPA Substance Registry System: Carbamic acid, [3-bromo-2-oxo-1-(phenylmethyl)propyl]-, 1,1-dimethylethyl ester, (S)-(68709-71-7)

Safety Data

• Hazardous Substances Data: 68709-71-7(Hazardous Substances Data)

Upstream product

• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 
• 74-95-3 1,1-dibromomethane 
• 119153-87-6 (C₅H₉O₂)C₉H₉NO(O)(CO₂C₂H₅) 
• 87694-53-9 Boc-Phe-OH N,O-dimethyl hydroxamate 
• 85613-64-5 (S)-3-(tert-butoxycarbonyl)amino-4-phenyl-2-butanone 
• 290836-34-9 (3S)-1,1-dibromo-3-tert-butoxycarbonylamino-4-phenyl-2-butanone 
• 67729-36-6 Boc-Phe-O-COO-isoBu 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 186581-53-3 diazomethane 

Downstream Products

• 136630-87-0 (2S,3S)-1-bromo-3-<(tert-butoxycarbonyl)amino>-4-phenyl-2-butanol 
• 136630-86-9 (2R,3S)-1-bromo-3-<(tert-butoxycarbonyl)amino>-4-phenyl-2-butanol 
• 140438-19-3 desmethyl JG₃₆₅ 
• 140925-28-6 desmethyl JG₃₆₅ 
• 388073-12-9 C₂₂H₂₉IN₂O₃ 
• 1361944-81-1 C₃₂H₄₀IN₃O₃ 
• 1375000-10-4 C₃₀H₃₅N₅O₈ 
• 1375000-16-0 C₂₂H₂₉N₅O₆ 
• 1402730-08-8 C₁₆H₂₂N₄O₂ 
• 1237501-99-3 C₁₈H₂₂N₄O₅ 
• 1237501-81-3 Boc-Phe-CH₂N₃ 
• 118405-09-7 [(S)-1-Benzyl-4-{(S)-1-[(S)-2-((S)-1-benzylcarbamoyl-3-methyl-butylcarbamoyl)-1-hydroxy-ethyl]-3-methyl-butylcarbamoyl}-2-hydroxy-5-(1H-imidazol-4-yl)-pentyl]-carbamic acid tert-butyl ester 
• 124339-04-4 Boc-PheΨGly-Sta-Leu-NHCH2Ph 
• 118388-87-7 2-((S)-3-tert-Butoxycarbonylamino-2-oxo-4-phenyl-butyl)-2-(1H-imidazol-4-ylmethyl)-malonic acid dibenzyl ester 

Relevant articles and documents

One-pot synthesis of orthogonally protected dipeptide selenazoles employing Nα-amino selenocarboxamides and α-bromomethyl ketones

A simple and efficient protocol for the synthesis of selenazole containing dipeptidomimetics using Nα-amino selenocarboxamides and α-bromomethyl ketones is described. All the compounds made were isolated in good yields and fully characterized.

Synthesis of N-urethane protected α-aminoalkyl-α-cyanomethyl ketones; Application to the synthesis of 3-substituted 5-amino-1H-pyrazole tethered peptidomimetics

The preparation of N-protected amino/peptide α-cyanomethyl ketones through cyanation of the corresponding α-bromomethyl ketones is described. The utility of the resulting α-cyanomethyl ketones in the synthesis of 3-substituted-5-amino-1H-pyrazoles has also been demonstrated. In both steps a wide range of N-protected amino/peptide acids has been employed and the products are obtained in good yield. The enantiomeric purity of both the α-cyanomethyl ketones and pyrazoles were confirmed by chiral HPLC analysis of the corresponding Z-protected d- and l-Ala-OH as model substrates. The synthesis of peptide pyrazolecarboxamides is also delineated. Georg Thieme Verlag Stuttgart · New York.

Amino acid derived epoxide ring opening under microwave irradiation

A solvent-free microwave-assisted methodology for the obtainment of the hydroxyethylamine (HEA) isostere is described. A phenylalanine derived aminoalkyl epoxide is allowed to react with a dipeptide amine using basic alumina partially deactivated with water under microwave irradiation. The HEA is obtained in very short time (3 min). This methodology is amenable to application in a parallel or automatic sequential format. Copyright