68716-52-9Relevant articles and documents
Development and Mechanistic Studies of Iron-Catalyzed Construction of Csp2-B Bonds via C-O Bond Activation
Geng, Shasha,Zhang, Juan,Chen, Shuo,Liu, Zhengli,Zeng, Xiaoqin,He, Yun,Feng, Zhang
supporting information, p. 5582 - 5588 (2020/07/08)
Herein we describe an iron-catalyzed borylation of alkenyl and aryl carbamates through the activation of a C-O bond. This protocol exhibits high efficiency, a broad substrate scope, and the late-stage borylation of biorelevant compounds, thus providing potential applications in medicinal chemistry. Moreover, this method enables orthogonal transformations of phenol derivatives and also offers good opportunities for the synthesis of multisubstituted arenes. Preliminary mechanistic studies suggest that a FeII/FeIII catalytic cycle via a radical pathway might be involved in the reaction.
Iron-Catalyzed Borylation of Aryl Chlorides in the Presence of Potassium t-Butoxide
Yoshida, Takumi,Ilies, Laurean,Nakamura, Eiichi
, p. 3199 - 3203 (2017/06/09)
A catalytic amount of an inorganic iron salt such as Fe(acac)3 catalyzes borylation of various aryl and heteroaryl chlorides with bis(pinacolato)diboron, where the presence of potassium t-butoxide is crucially important. The alkoxide is considered to produce in situ an electron-rich iron alkoxide complex as the active species. The reaction requires only an iron salt and potassium t-butoxide as promoters and is easily scalable. The arylboron compound prepared by this reaction can be further coupled in situ with an aryl halide under the Suzuki-Miyaura conditions.
Application of cooperative iron/copper catalysis to a palladium-free borylation of aryl bromides with pinacolborane
Labre, Flavien,Gimbert, Yves,Bannwarth, Pierre,Olivero, Sandra,Dunach, Elisabet,Chavant, Pierre Y.
supporting information, p. 2366 - 2369 (2014/05/20)
A new cooperative copper/iron catalysis for the borylation of various aryl bromides with pinacolborane, at -10 °C, is reported. Use of the toxic, precious metal Pd is avoided. The mechanism of the protodebromination side reaction is discussed.
