6874-60-8Relevant articles and documents
Synthesis of Long-Chain n-Alkylphosphonic Acids by Phosphonylation of Alkyl Bromides with Red Phosphorus and Superbase under Micellar/Phase Transfer Catalysis
Kuimov, Vladimir A.,Malysheva, Svetlana F.,Belogorlova, Natalia A.,Albanov, Alexander I.,Gusarova, Nina K.,Trofimov, Boris A.
supporting information, p. 1596 - 1602 (2021/03/03)
Long-chain n-Alkylphosphonic acids, AlkP(O)(OH)2, are synthesized in up to 91 % yield (mostly 40–60 %) by straightforward phosphonylation of alkyl bromides (AlkBr, Alk=C4–C18) with red phosphorus (Pn) in the multiphase KOH/H2O/toluene system in the presence of 2–10 mol % of cetyltrimethylammonium bromide (CTAB), acting as a micellar/phase transfer catalyst and as a generator/transporter of superbasic hydroxide anions, the intermediate potassium phosphinates being in situ oxidized/neutralized by nitric acid. The key steps of the phosphonylation mechanism are the P?P bond cleavage of Pn polymeric molecules by superbasic ?OH anions, dissolved in the CTAB micelles, and phase transfer of polyphosphide anions to the organic phase and their alkylation with AlkBr.
Supercritical hydrothermal synthesis of carboxylic acid-surface- functionalized TiO2 nanocrystals: PH sensitive dispersion and hybridization with organic compounds
Arita, Toshihiko,Moriya, Ken-Ichi,Minami, Kimitaka,Naka, Takashi,Adschiri, Tadafumi
supporting information; experimental part, p. 961 - 963 (2011/01/05)
Surface-functionalized TiO2 (anatase) nanocrystals (NCs) (avg. d=6.7±1.6nm) were synthesized by a supercritical hydrothermal method. A phosphonic acid derivative was used as surface modifier of TiO2 NCs. It was verified that the phosphonic acids were bound to the surface of TiO 2 with very strong binding energy. The TiO2 NCs also exhibited extraordinarily high chemical stability. Such a strong binding between the phosphonic acid modifier and TiO2 had not been obtained by any other methods. The TiO2 NC showed sharp pH sensitive dispersion. Because of the functional as well as stable surface modifier layer, further manipulations on the surface using chemical reagents could be possible.
Phosphorus containing compounds as antihypercholesterolemic and antiatherosclerotic agents
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, (2008/06/13)
Novel phosphorus containing compounds are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful in preventing the intestinal absorption of cholesterol and thus are useful in the treatment of hypercholesterolemia and atherosclerosis.