68820-79-1

Basic information

• Product Name: methyl (2S,1'S)-1-(1'-phenyl-ethyl)-aziridine-2-carboxylate
• Synonyms: methyl (2S,1'S)-1-(1'-phenyl-ethyl)-aziridine-2-carboxylate
• CAS NO: 68820-79-1
• Molecular Weight: 205.257
• Mol File: 68820-79-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl (2S,1'S)-1-(1'-phenyl-ethyl)-aziridine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2S,1'S)-1-(1'-phenyl-ethyl)-aziridine-2-carboxylate(68820-79-1)
• EPA Substance Registry System: methyl (2S,1'S)-1-(1'-phenyl-ethyl)-aziridine-2-carboxylate(68820-79-1)

Safety Data

• Hazardous Substances Data: 68820-79-1(Hazardous Substances Data)

Upstream product

• 1729-67-5 Methyl 2,3-dibromopropionate 
• 2627-86-3 (S)-1-phenyl-ethylamine 

Downstream Products

• 1315320-57-0 diphenyl-((S)-1-((S)-1-phenylethyl)aziridin-2-yl)-methanol 
• 398511-44-9 (S)-1-((S)-1-phenylethyl)aziridine-2-carbaldehyde 
• 945676-62-0 C₁₇H₂₆NO₅P 
• 945676-55-1 diethyl (S)-hydroxy{(S)-1-[(S)-1-phenylethyl]aziridin-2-yl}methylphosphonate 
• 216597-58-9 N-[(S)-α-phenylethyl]aziridin-2(S)-yl-methanol 

Relevant articles and documents

Applications of conformational design: Rational resign of chiral ligands derived from a common chiral source for highly enantioselective preparations of (R)- and (S)-enantiomers of secondary alcohols

A pair of diastereomers 7 and 8 were easily synthesized in only two steps from a single common chiral source according to the concept of conformation design. The efficiency of these chiral ligands was evaluated by their application to the asymmetric addition of diethylzinc to aldehydes. This catalytic asymmetric process afforded the a most efficient access to the (R)- and (S)-enantiomers of a given secondary alcohol with similarly outstanding enantioselectivities and high yields. Our results also showed that the control of the desired conformer's population by conformation design is a new and practical strategy for the rational and precise design of highly enantioselective chiral ligands for metal-catalyzed reactions. The mechanism and possible transition states for the catalytic asymmetric addition have been proposed on the basis of previous studies as well as the crystal structure of the chiral ligands 7 and 8.

METHODS FOR TREATING CHRONIC PAIN USING 1-BENZYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES,3-BENZYL-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS

Disclosed herein are methods of treating a patient suffering from one or more types of chronic pain using the following compounds: