688363-79-3

Basic information

• Product Name: Benzene, 1-bromo-3-nitro-2-(phenylmethoxy)-
• CAS NO: 688363-79-3
• Molecular Formula: C13H10BrNO3
• Molecular Weight: 308.131
• Mol File: 688363-79-3.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzene, 1-bromo-3-nitro-2-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-bromo-3-nitro-2-(phenylmethoxy)-(688363-79-3)
• EPA Substance Registry System: Benzene, 1-bromo-3-nitro-2-(phenylmethoxy)-(688363-79-3)

Safety Data

• Hazardous Substances Data: 688363-79-3(Hazardous Substances Data)

Usage

Description

Benzene, 1-bromo-3-nitro-2-(phenylmethoxy)-, also known as 1-Bromo-3-nitro-2-anisylbenzene, is an organic compound with the molecular formula C13H10BrNO4. It is a colorless to pale yellow liquid that serves as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Additionally, it is utilized in the production of dyes and other organic compounds. Due to its toxic nature and potential to cause irritation to the skin, eyes, and respiratory system, it is crucial to handle, store, and dispose of this compound with care and follow safety precautions.

Uses

Used in Pharmaceutical Industry:
Benzene, 1-bromo-3-nitro-2-(phenylmethoxy)is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, Benzene, 1-bromo-3-nitro-2-(phenylmethoxy)is employed as an intermediate in the production of agrochemicals, contributing to the development of pesticides and other agricultural products that help improve crop yields and protect plants from pests.
Used in Dye Production:
Benzene, 1-bromo-3-nitro-2-(phenylmethoxy)is utilized in the manufacturing process of dyes, where its chemical properties contribute to the creation of a wide range of colors and hues for various applications, including textiles, plastics, and printing inks.
Used in Organic Compounds Synthesis:
Benzene, 1-bromo-3-nitro-2-(phenylmethoxy)is also used in the synthesis of other organic compounds, expanding its applications across different industries that rely on organic chemistry for the development of new products and materials.

Upstream product

• 88-75-5 2-hydroxynitrobenzene 
• 13073-25-1 2-bromo-6-nitro-phenol 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 

Downstream Products

• 1097777-69-9 ethyl 3-({3-nitro-2-[(phenylmethyl)oxy]phenyl}amino)benzoate 
• 376592-93-7 3′-amino-2′-hydroxy biphenyl-3-carboxylic acid 
• 1916-59-2 2-aminophenoxazin-3-one 
• 376591-97-8 3'-amino-2'-hydroxy-1,1'-biphenyl-3-carboxylic acid hydrochloride 
• 1097777-70-2 ethyl 3-[(3-amino-2-hydroxyphenyl)amino]benzoate 
• 688363-78-2 4-(2-benzyloxy-3-nitro-phenyl)-piperazine-1-carboxylic Acid Tert-butyl Ester 

Relevant articles and documents

Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl) -1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors

G-protein-coupled receptor kinase (GRK)-2 and -5 are emerging therapeutic targets for the treatment of cardiovascular disease. In our efforts to discover novel small molecules to inhibit GRK-2 and -5, a class of compound based on 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine was identified as a novel hit by high throughput screening campaign. Structural modification of parent benzoxazole scaffolds by introducing substituents on phenyl displayed potent inhibitory activities toward GRK-2 and -5.

JAK INHIBITORS

Disclosed is a series of JAK inhibitors, which specifically relates to a compound shown in formula (I) or pharmaceutically acceptable salts thereof.

Unexpected one pot C (aryl)-N bond cleavage and Questiomycin A formation from the reduction reaction of 2-amino-6-nitrophenol derivatives

2-Amino-6-nitrophenol derivatives 5A and 5B have been prepared from the bromonitro phenol derivative 4 using the Buchwald conditions. While attempting one pot reduction of nitro group and deprotection of phenolic benzyl group of the compounds 5A and 5B separately using Pd/C in methanol under H2 atmosphere, an unexpected C(aryl)-N bond cleavage reaction had occurred which was followed by formation of a known compound Questiomycin A (2-amino-3H-phenoxazin-3-one) 1 from both the compounds. In the present study, the danger of deamination of Buchwald products 5A and 5B under the conditions of catalytic hydrogenation and the simultaneous formation of phenoxazine 1 is disclosed.