68839-08-7

Basic information

• Product Name: Phosphonic acid, (1-amino-2-phenylethyl)-, diethyl ester, (S)-
• CAS NO: 68839-08-7
• Molecular Formula: C12H20NO3P
• Molecular Weight: 257.269
• Mol File: 68839-08-7.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, (1-amino-2-phenylethyl)-, diethyl ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, (1-amino-2-phenylethyl)-, diethyl ester, (S)-(68839-08-7)
• EPA Substance Registry System: Phosphonic acid, (1-amino-2-phenylethyl)-, diethyl ester, (S)-(68839-08-7)

Safety Data

• Hazardous Substances Data: 68839-08-7(Hazardous Substances Data)

Upstream product

• 139623-43-1 (S)-2-[(E)-1-(Diethoxy-phosphoryl)-2-phenyl-ethylimino]-7,7-dimethyl-bicyclo[2.2.1]heptane-1-carboxylic acid 
• 104549-56-6 (1R,4S)-<2-Phenyl-1-(1,7,7-trimethylbicyclo<2.2.1>hept-2-ylidenamino)ethyl>phosphonsaeure-diethylester 
• 141207-39-8 ((S)-1-Azido-2-phenyl-ethyl)-phosphonic acid diethyl ester 
• 220586-54-9 diethyl(-)-(2S,3R)-(3-phenyl-2-H-aziridin-2-yl) phosphonate 
• 558449-13-1 diethyl(+)-(3S)-[2-phenyl-1-(p-toluenesulfonylamino)ethyl] phosphonate 
• 66609-42-5 D-Phenylalanine phosphonate 
• 122-51-0 orthoformic acid triethyl ester 
• 3167-63-3 diethyl chloromethylphosphonate 
• 10419-77-9 diethyl iodomethanephosphonate 
• 350479-90-2 (S,E)-N-benzylidene-4-methylbenzenesulfinamide 
• 220586-52-7 diethyl (S_s,2S,3R)-(-)-N-(p-toluenesulfinyl)-3-phenylaziridine-2-phosphonate 
• 220586-50-5 diethyl (S_s,1S,2R)-1-chloro-2-phenyl-2-(p-toluenesulfinamido)ethylphosphonate 
• 73270-44-7 diphenyl (1-amino-2-phenyl)ethylphosphonate 
• 289506-28-1 diphenyl (1-(N-tert-butoxycarbonylamino)-2-phenyl)ethylphosphonate 

Relevant articles and documents

Chirality-Driven Mode of Binding of α-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS)

Thienopyrimidine-based allosteric inhibitors of the human farnesyl pyrophosphate synthase (hFPPS), characterized by a chiral α-aminophosphonic acid moiety, were synthesized as enantiomerically enriched pairs, and their binding mode was investigated by X-ray crystallography. A general consensus in the binding orientation of all (R)- and (S)-enantiomers was revealed. This finding is a prerequisite for establishing a reliable structure-activity relationship (SAR) model.

Asymmetric synthesis of aziridine 2-phosphonates from enantiopure sulfinimines (N-sulfinyl imines). Synthesis of α-amino phosphonates

An aza-Darzens reaction, involving the addition of chloromethylphosphonate anions to enantiopure sulfinimines, has been developed for the asymmetric synthesis of aziridine 2-phosphonates. Best results involve cyclization of the syn and anti diastereomeric

Asymmetric synthesis of aziridinyl phosphonates using Darzens-type reaction of chloromethyl phosphonate to chiral sulfinimines

Darzens-type reaction of chloromethyl phosphonate with (S)-(+)-N- sulfinimines gave (Ss, 2S, 3R)-diethyl 3-aryl-2-N-(p- toluenesulfinyl)aziridinylphosphonate (3) in good yields.