68943-85-1Relevant articles and documents
3-Alkylthio-1,2,4-triazine dimers with potent antimalarial activity
Ban, Kung,Duffy, Sandra,Khakham, Yelena,Avery, Vicky M.,Hughes, Andrew,Montagnat, Oliver,Katneni, Kasiram,Ryan, Eileen,Baell, Jonathan B.
, p. 6024 - 6029 (2010)
We report on the discovery of 3-alkylthio-1,2,4-triazine dimers that are potently toxic to Plasmodium falciparum, with single digit nanomolar activity, and up to several thousand-fold lower toxicity to mammalian cells. They are equipotent against chloroquine-resistant strains of P. falciparum.