68965-62-8

Basic information

• Product Name: 1-Cyclohexene-1-carboxylic acid, 2-bromo-
• CAS NO: 68965-62-8
• Molecular Formula: C7H9BrO2
• Molecular Weight: 205.051
• Mol File: 68965-62-8.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1-Cyclohexene-1-carboxylic acid, 2-bromo-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Cyclohexene-1-carboxylic acid, 2-bromo-(68965-62-8)
• EPA Substance Registry System: 1-Cyclohexene-1-carboxylic acid, 2-bromo-(68965-62-8)

Safety Data

• Hazardous Substances Data: 68965-62-8(Hazardous Substances Data)

Usage

Description

1-Cyclohexene-1-carboxylic acid, 2-bromois an organic chemical compound characterized by the molecular formula C8H11BrO2. It features a cyclohexene ring fused with a carboxylic acid group, and a bromine atom attached at the 2-position. 1-Cyclohexene-1-carboxylic acid, 2-bromois recognized for its versatility and reactivity in organic chemistry, making it a valuable component in various chemical processes and syntheses.

Uses

Used in Organic Synthesis:
1-Cyclohexene-1-carboxylic acid, 2-bromoserves as a key intermediate in organic synthesis, facilitating the creation of a wide range of chemical products. Its unique structure allows for multiple reaction pathways, contributing to the diversity of synthesized compounds.
Used in Pharmaceutical Production:
1-Cyclohexene-1-carboxylic acid, 2-bromois utilized in the production of pharmaceuticals due to its potential to be incorporated into drug molecules. Its presence can influence the pharmacological properties of the final product, such as activity, selectivity, and stability.
Used in Agrochemicals:
1-Cyclohexene-1-carboxylic acid, 2-bromois also employed in the development of agrochemicals, which are chemicals used in agricultural or horticultural settings. Its role can be pivotal in enhancing crop protection products or in developing new pesticides.
Used as a Starting Material for Derivatives:
1-Cyclohexene-1-carboxylic acid, 2-bromocan be used as a starting material for the synthesis of various derivatives. This allows for the exploration of new chemical entities and the expansion of the chemical library for research and development purposes.
Involved in Chemical Reactions:
Due to its reactivity, 1-Cyclohexene-1-carboxylic acid, 2-bromocan participate in a variety of chemical reactions, such as substitution, addition, and elimination reactions. This makes it a useful tool for advancing chemical knowledge and developing new methodologies in organic chemistry.

Upstream product

• 108-94-1 cyclohexanone 
• 72422-64-1 2-bromocyclohex-1-ene-1-carboxylic acid methyl ester 
• 38127-47-8 2-bromocyclohex-1-ene-1-carbaldehyde 

Downstream Products

• 552857-10-0 2-bromo-N-phenyl-1-cyclohexene-1-carboxamide 
• 122135-92-6 (3Z)-4,5,6,7-tetrahydro-3-benzylideneisobenzofuran-1(3H)-one 
• 2426-02-0 3,4,5,6-Tetrahydrophthalic anhydride 
• 121032-80-2 3-[1-p-Tolyl-meth-(E)-ylidene]-4,5,6,7-tetrahydro-3H-isobenzofuran-1-one 
• 1601483-05-9 4,5,6,7-tetrahydro-2-(phenylamino)-2H-isoindole-1,3-dione 

Relevant articles and documents

SELECTIVE PHOSPHATASE INHIBITORS BASED ON ILLUDALIC ACID

The present disclosure provides novel selective phosphatase inhibitor compounds based on illudalic acid. The present disclosure provides a streamlined method of synthesizing illudalic acid and a method for synthesizing phosphatase inhibitor compounds. The method of this invention provides convergent benzannulation of β-keto amides and esters, followed by a one-pot reduction / hydrolysis sequence. The concise synthetic approach provided by this invention enables rapid assembly of illudalog compounds of this invention that are potent protein tyrosine phosphatase receptor-type D (PTPRD) inhibitors.

Structure-activity relationship study of non-steroidal NPC1L1 ligands identified through cell-based assay using pharmacological chaperone effect as a readout

Niemann-Pick type C1-like 1 (NPC1L1) is an intestinal cholesterol transporter that is known to be the target of the cholesterol absorption inhibitor ezetimibe. We previously discovered steroidal NPC1L1 ligands by using a novel cell-based assay that employs pharmacological chaperone effect as a readout. Those steroid derivatives bound to a site different from both the sterol-binding domain and the ezetimibe-binding site, implying that they may be a novel class of NPC1L1 inhibitors with a distinct mode of action. As an extension of that work, we aimed here to find non-steroidal NPC1L1 ligands, which may be better candidates for clinical application than steroidal ligands, by using the same assay to screen our focused library of ligands for liver X receptor (LXR), a nuclear receptor that recognizes oxysterols as endogenous ligands. Here we describe identification of a novel class of NPC1L1 ligands with a ring-fused quinolinone scaffold, and an analysis of the structure-activity relationships of their derivatives as NPC1L1 ligands.

Palladium-catalyzed carbonylative cyclization of β-Bromo-α, β-unsaturated carboxylic acids leading to maleic anhydrides

β-Bromo-α,β-unsaturated carboxylic acids are carbonylatively cyclized under carbon monoxide pressure in acetic acid in the presence of a catalytic amount of a palladium catalyst along with a base to give the corresponding maleic anhydrides in high yields. Georg Thieme Verlag Stuttgart · New York.