68981-78-2

Basic information

• Product Name: Pyridine, 3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-1,4-dihydro-4-phenyl-
• CAS NO: 68981-78-2
• Molecular Formula: C16H18N2O
• Molecular Weight: 254.332
• Mol File: 68981-78-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Pyridine, 3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-1,4-dihydro-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-1,4-dihydro-4-phenyl-(68981-78-2)
• EPA Substance Registry System: Pyridine, 3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-1,4-dihydro-4-phenyl-(68981-78-2)

Safety Data

• Hazardous Substances Data: 68981-78-2(Hazardous Substances Data)

Upstream product

• 59-67-6 nicotinic acid 
• 20260-53-1 pyridine-3-carbonyl chloride hydrochloride 
• 93-60-7 methyl 3-pyridinecarboxylate 
• 68981-86-2 3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)pyridine 
• 591-51-5 phenyllithium 

Relevant articles and documents

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SOLVENT AND TEMPERATURE EFFECTS ON THE NUCLEOPHILIC ADDITION OF ORGANOLITHIUMS TO 3-(4,4-DIMETHYLOXAZOLIN-2-YL)PYRIDINE. SYNTHESIS OF STABILIZED 1,2-, 1,4- AND/OR 1,6-DIHYDROPYRIDINES

The reaction of 3-(4,4-dimethyloxazolin-2-yl)pyridine (1) with nucleophilic organolithium reagents afforded stabilized N-unsubstituted 1,2-, 1,4- and/or 1,6-dihydropyridines.Reaction of 1 with phenyllithium gave a mixture of 1,2- (2) and 1,4-dihydropyridi

Substitutions on Pyridines Activated by Oxazolines via Nucleophilic Additions or Metalation-Alkylation

Pyridyloxazolines, derived from nicotinic acid or isonicotinic acid, have been shown to metalate at the 4- and 3-positions, respectively.These react with a variety of electrophiles to provide 4- and 3-substituted pyridines in good yield.Alternatively, 3-pyridyloxazolines, when treated with organolithium or Grignard reagents, give addition to the 4-position and provide a series of 4-substituted 1,4-dihydropyridines.