69037-98-5

Basic information

• Product Name: Carbamic acid, (4-oxobutyl)-, phenylmethyl ester
• CAS NO: 69037-98-5
• Molecular Formula: C12H15NO3
• Molecular Weight: 221.256
• Mol File: 69037-98-5.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Carbamic acid, (4-oxobutyl)-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (4-oxobutyl)-, phenylmethyl ester(69037-98-5)
• EPA Substance Registry System: Carbamic acid, (4-oxobutyl)-, phenylmethyl ester(69037-98-5)

Safety Data

• Hazardous Substances Data: 69037-98-5(Hazardous Substances Data)

Upstream product

• 5105-78-2 4-(benzyloxycarbonylamino)butyric acid 
• 197891-66-0 4-benzyloxycarbamate-butyraldehyde diethyl acetal 
• 868775-53-5 N-Cbz-4-aminobutylaldehyde dimethylacetal 
• 201230-82-2 carbon monoxide 
• 5041-33-8 N-(Benzyloxycarbonyl)allylamine 
• 67706-63-2 4-benzyloxycarbonylaminobutyric acid methyl ester 
• 501-53-1 benzyl chloroformate 
• 17996-13-3 benzyl 4-hydroxybutylcarbamate 

Downstream Products

• 1585236-10-7 pinacol (R)-3-(((benzyloxy)carbonyl)amino)-1-((R)-tert-butanesulfinamido)propylboronate 
• 1447956-85-5 C₁₇H₂₀N₂O₄S 
• 1381763-94-5 benzyl (4-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)butyl)carbamate 
• 1381761-17-6 C₂₆H₃₅N₇O₅ 
• 1206601-69-5 [4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-butyl]-carbamic acid benzyl ester 
• 114684-73-0 Cbz-δLyz(Cbz)-OH 

Relevant articles and documents

COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS

The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

Easily accessible and highly tunable bisphosphine ligands for asymmetric hydroformylation of terminal and internal alkenes

An efficient methodology for synthesizing a small library of easily tunable and sterically bulky ligands for asymmetric hydroformylation (AHF) has been reported. Five groups of alkene substrates have been tested with excellent conversions, moderate-to-excellent regio- and enantioselectivities. Among the best result of the reported literature, application of ligand 1 c in the highly selective AHF of the challenging substrate 2,5-dihydrofuran yielded almost one isomer in up to 99 % conversion along with enantiomeric excesses (ee) of up to 92 %. Highly enantioselective AHF of dihydropyrrole substrates is achieved using the same ligand, with up to 95 % ee and up to >1:50 β-isomer/α- isomer ratio. The simpler the better! An efficient method for the easy and tunable synthesis of a series of asymmetric hydroformylation (AHF) ligands from low-cost, commercially available starting materials has been reported. These ligands can give excellent conversions and moderate to excellent regio- and enantioselectivities for a broad range of mono- and disubstituted alkenes with a low catalyst loading (substrate-to-catalyst ratios (S/C) of 1000:1 to 3000:1).

Enantioselective hydroformylation of N-vinyl carboxamides, allyl carbamates, and allyl ethers using chiral diazaphospholane ligands

Rhodium complexes of diazaphospholane ligands catalyze the asymmetric hydroformylation of N-vinyl carboxamides, allyl ethers, and allyl carbamates; products include 1,2- and 1,3-aminoaldehydes and 1,3-alkoxyaldehydes. Using glass pressure bottles, short reaction times (generally less than 6 h), and low catalyst loading (commonly 0.5 mol %), 20 substrates are successfully converted to chiral aldehydes with useful regioselectivity and high enantioselectivity (up to 99% ee). Chiral Roche aldehyde is obtained with 97% ee from the hydroformylation of allyl silyl ethers. Commonly difficult substrates such as 1,1- and 1,2-disubstituted alkenes undergo effective hydroformylation with 89-97% ee and complete conversion for six examples. Palladium-catalyzed aerobic oxidative amination of allyl benzyl ether followed by enantioselective hydroformylation yields the β3-aminoaldehyde with 74% ee.