69048-76-6 Usage
Description
(6-iodobenzo[1,3]dioxol-5-yl)methanol is a chemical compound characterized by its molecular formula C8H7IO3. It is a derivative of benzo[1,3]dioxole, a structural motif prevalent in numerous natural and synthetic compounds. (6-iodobenzo[1,3]dioxol-5-yl)methanol's unique feature is the presence of an iodine atom and a hydroxyl group, which contribute to its potential utility in various scientific and industrial applications. These include organic synthesis, medicinal chemistry, and material science, where it can serve as a building block for more complex organic compounds or act as a reagent in diverse chemical reactions. Furthermore, due to its structural resemblance to other bioactive molecules containing a benzo[1,3]dioxole moiety, (6-iodobenzo[1,3]dioxol-5-yl)methanol may also possess potential biological activities.
Uses
Used in Organic Synthesis:
(6-iodobenzo[1,3]dioxol-5-yl)methanol is used as a building block for the synthesis of more complex organic compounds. Its unique structure, including the iodine atom and hydroxyl group, allows for the creation of a wide range of molecules with various applications in different industries.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (6-iodobenzo[1,3]dioxol-5-yl)methanol is utilized as a reagent in various chemical reactions. Its structural similarity to bioactive molecules makes it a promising candidate for the development of new pharmaceuticals and therapeutic agents.
Used in Material Science:
(6-iodobenzo[1,3]dioxol-5-yl)methanol is also employed in material science, where its unique properties can be harnessed to develop new materials with specific characteristics and applications.
Overall, (6-iodobenzo[1,3]dioxol-5-yl)methanol is a versatile compound with potential applications in various fields of science and industry, including organic synthesis, medicinal chemistry, and material science. Its unique structure and properties make it a valuable asset for researchers and scientists working in these areas.
Check Digit Verification of cas no
The CAS Registry Mumber 69048-76-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,9,0,4 and 8 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 69048-76:
(7*6)+(6*9)+(5*0)+(4*4)+(3*8)+(2*7)+(1*6)=156
156 % 10 = 6
So 69048-76-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H7IO3/c9-6-2-8-7(11-4-12-8)1-5(6)3-10/h1-2,10H,3-4H2
69048-76-6Relevant articles and documents
Cobalt-catalyzed regioselective carbocyclization reaction of o-iodophenyl ketones and aldehydes with alkynes, acrylates, and acrylonitrile: A facile route to indenols and indenes
Chang, Kuo-Jui,Rayabarapu, Dinesh Kumar,Cheng, Chien-Hong
, p. 4781 - 4787 (2007/10/03)
An efficient cobalt-catalyzed carbocylization for the synthesis of indenols and indenes and a new method for reductive decyanation are described. 2-Iodophenyl ketones and aldehydes 1a-g undergo carbocyclization with various disubstituted alkynes 2a-k in the presence of Co(dppe)I2 and zinc powder in acetonitrile at 80 °C for 3 h to afford the corresponding indenol derivatives 3a-s and 4a-m in good to excellent yields. For some unsymmetrical alkynes, the carbocyclization was remarkably regioselective, affording a single regioisomer. The cobalt-catalyzed carbocyclization reaction was successfully extended to the synthesis of indene derivatives. Thus, the reaction of 2-iodophenyl ketones and aldehydes (1) with acrylates H2C=CHCO 2R (7a-d) and acrylonitrile H2C= CHCN (7e) proceeds smoothly in the presence of Co(dppe)Cl2/dppe and zinc powder in acetonitrile at 80 °C for 24 h to afford the corresponding indenes 8a-k and 9a-c in moderate to good yields. Interestingly, when 7e was employed for the carbocylization, reductive decyanation also occurred to give an indene derivative without the cyano functionality. A possible mechanism for this cobalt-catalyzed carbocyclization reaction is also proposed.
