690632-17-8

Basic information

• Product Name: 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1-(TRIISOPROPYLSILYL)-1H-INDOLE
• Synonyms: 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1-(TRIISOPROPYLSILYL)-1H-INDOLE;1-(Triisopropylsilyl)-1H-indole-4-boronic acid, pinacol ester;4-(4,4,5,5-Tetramethyl-1,2,3-dioxaborolan-2-yl)-1-(triisopropylsilyl)-1H-indole;1-(triisopropylsilyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole;1-Tris(isopropylsilyl)-1H-indole-4-boronic acid, pinacol ester;2-dioxaborolan-2-yl)-1-(triisopropylsilyl)-1H-indole;4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tris(isopropylsilyl)-1H-indole
• CAS NO: 690632-17-8
• Molecular Formula: C₂₃H₃₈BNO₂Si
• Molecular Weight: 399.45
• Mol File: 690632-17-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 433.7 °C at 760 mmHg
• Flash Point: 216.1 °C
• Appearance: /
• Density: 0.98 g/cm³
• Vapor Pressure: 1.01E-07mmHg at 25°C
• Refractive Index: 1.505
• CAS DataBase Reference: 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1-(TRIISOPROPYLSILYL)-1H-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1-(TRIISOPROPYLSILYL)-1H-INDOLE(690632-17-8)
• EPA Substance Registry System: 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1-(TRIISOPROPYLSILYL)-1H-INDOLE(690632-17-8)

Safety Data

• Hazardous Substances Data: 690632-17-8(Hazardous Substances Data)

Usage

General Description

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(triisopropylsilyl)-1H-indole is a complex chemical compound with a unique structure. It contains a boron-containing ring and a triisopropylsilyl group, both of which have important functions in organic synthesis. The compound has potential applications in the field of medicinal chemistry as well as in the development of new materials. It may also be used as a building block in the synthesis of more complex organic molecules. Due to its specific structure and properties, this compound is of interest to researchers in various scientific fields as a potential tool for the development of new technologies and materials.

InChI:InChI=1/C23H38BNO2Si/c1-16(2)28(17(3)4,18(5)6)25-15-14-19-20(12-11-13-21(19)25)24-26-22(7,8)23(9,10)27-24/h11-18H,1-10H3

Upstream product

• 73183-34-3 bis(pinacol)diborane 
• 52488-36-5 4-bromo-1H-indole 
• 13154-24-0 triisopropylsilyl chloride 
• 388116-27-6 indole-4-boronic acid pinacol ester 

Downstream Products

• 915411-38-0 [4-benzyloxy-6-(1-triisopropylsilanyl-1H-indol-4-yl)-pyrimidin-2-yl]-pyridin-3-yl-amine 
• 915411-45-9 N-(pyridin3-yl)-N-(3-(1-(triisopropylsilyl)-1H-indol-4-yl)phenyl)acetamide 
• 915411-50-6 [3-(4-methoxy-benzylooxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-(1-oxy-pyridin-3-yl)-amine 
• 915411-54-0 (6-benzyloxy-pyridin-3-yl)-[3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-amine 
• 915411-90-4 Acetic acid 5-[3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-benzoyl]-pyridin-2-ylmethyl ester 
• 915412-20-3 4-(3-bromo-5-(4-methoxybenzyloxy)phenyl)-1-(triisopropylsilyl)-1H-indole 
• 915412-25-8 [3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-(6-methoxy-pyridin-3-yl)-methanone 
• 915412-39-4 [3-(pyridine-3-carbonyl)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-carbamic acid methyl ester 
• 915411-28-8 (3-(4-methoxybenzyloxy)-5-(1-(triisopropylsilyl)-1H-indol-4-yl)phenyl)(pyridin-3-yl)methanone 
• 915411-80-2 N-(3-(1H-indol-4-yl)-5-methoxyphenyl)pyridin-3-amine 
• 915411-91-5 (6-hydroxymethyl-pyridin-3-yl)-[3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-methanone 
• 915411-43-7 N-(3-(1H-indol-4-yl)phenyl)-N-(pyridin-3-yl)acetamide 
• 915411-31-3 [3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-pyridin-3-yl-methanone oxime 
• 915412-21-4 [3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-phenyl-amine 

Relevant articles and documents

Anti-cancer agents and uses thereof

The present invention is in the area of novel compounds and salts thereof, their syntheses, and their use as anti-cancer agents. The compounds include compounds of Formula I: and solvates, hydrates and pharmaceutically-acceptable salts thereof, wherein A1 is N or CR1; A3 is N or CR3; A5 is N or CR5; R1, R3-R6 and L are defined in the specification; n is 0 or 1; and X is an optionally-substituted aryl group having 6-10 carbons in the ring portion, an optionally-substituted 6-membered heteroaryl group having 1-3 nitrogen atoms in the ring portion, an optionally-substituted 5-membered heteroaryl group having 0-4 nitrogen atoms in the ring portion and optionally having 1 sulfur atom or 1 oxygen atom in the ring portion, or an optionally-substituted heteroaryl group in which a 6-membered ring is fused either to a 5-membered ring or to a 6-membered ring, wherein in each case 1, 2, 3 or 4 ring atoms are heteroatoms independently selected from nitrogen, oxygen and sulfur. They are effective against a broad range of cancers, especially leukemia, prostate, non-small cell lung and colon. They are additionally useful in the treatment of proliferative retinopathies such as diabetic neuropathy and macular degeneration.

Anti-cancer agents and uses thereof

The present invention is in the area of novel compounds and salts thereof, their syntheses, and their use as anti-cancer agents. The compounds include compounds of Formula I: and solvates, hydrates and pharmaceutically-acceptable salts thereof, wherein A1 is N or CR1; A3 is N or CR3; A5 is N or CR5; R1, R3—R6 and L are defined in the specification; n is 0 or 1; and X is an optionally-substituted aryl group having 6-10 carbons in the ring portion, an optionally-substituted 6-membered heteroaryl group having 1-3 nitrogen atoms in the ring portion, an optionally-substituted 5-membered heteroaryl group having 0-4 nitrogen atoms in the ring portion and optionally having 1 sulfur atom or 1 oxygen atom in the ring portion, or an optionally-substituted heteroaryl group in which a 6-membered ring is fused either to a 5-membered ring or to a 6-membered ring, wherein in each case 1, 2, 3 or 4 ring atoms are heteroatoms independently selected from nitrogen, oxygen and sulfur. They are effective against a broad range of cancers, especially leukemia, non-small cell lung and colon.