69085-39-8

Basic information

• Product Name: 4-[(4-methylphenyl)amino]naphthalene-1,2-dione
• Synonyms: 1,2-Naphthalenedione, 4-[(4-methylphenyl)amino]-; 4-(4-Toluidino)-1,2-naphthalenedione
• CAS NO: 69085-39-8
• Molecular Formula: C₁₇H₁₃NO₂
• Molecular Weight: 263.2906
• Mol File: 69085-39-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 440.7°C at 760 mmHg
• Flash Point: 170.9°C
• Density: 1.304g/cm³
• Vapor Pressure: 5.76E-08mmHg at 25°C
• Refractive Index: 1.688
• CAS DataBase Reference: 4-[(4-methylphenyl)amino]naphthalene-1,2-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(4-methylphenyl)amino]naphthalene-1,2-dione(69085-39-8)
• EPA Substance Registry System: 4-[(4-methylphenyl)amino]naphthalene-1,2-dione(69085-39-8)

Safety Data

• Hazardous Substances Data: 69085-39-8(Hazardous Substances Data)

Usage

General Description

4-[(4-Methylphenyl)amino]naphthalene-1,2-dione, often recognized by its CAS number 34942-02-8, is an organic compound that falls within the chemical category of Aminonaphthoquinones. 4-[(4-methylphenyl)amino]naphthalene-1,2-dione is primarily incorporated in the development of pharmaceutical drugs and research. Its complex structure incorporates naphthalene, a polycyclic aromatic hydrocarbon, with a dione group, which contains two ketone groups, and an amino group bonded with a methylphenyl ring. So far, it has not been classified, meaning risks and hazards associated with this chemical are not fully identified yet. Therefore, it's crucial to handle it with caution in laboratory or industrial environments.

Upstream product

• 7664-93-9 sulfuric acid 
• 521-24-4 sodium 1,2-naphthoquinone-4-sulfonate 
• 106-49-0 p-toluidine 
• 36417-25-1 2-hydroxy-1,4-naphthoquinone silver salt 
• 18916-57-9 4-methoxy-1,2-naphthoquinone 
• 7732-18-5 water 
• 524-42-5 1,2-naphthoquinone 
• 124554-09-2 4-p-toluidino-[1,2]naphthoquinone-1-p-tolylimine 

Downstream Products

• 57182-49-7 2-(p-toluidino)-1,4-naphthoquinone 
• 114599-44-9 2-cyclohexylamino-[1,4]naphthoquinone-4-p-tolylimine 
• 83-72-7 2-hydroxynaphtho-1,4-quinone 
• 106-49-0 p-toluidine 
• 67979-43-5 2-(4-methylanilino)-4-[(4-methylphenyl)imino]naphthalen-1(4H)-one 
• 1427067-62-6 9-methylbenzo[a]phenazine-5,6-dione 7-oxide 
• 120130-65-6 5-p-tolylbenzo[a]phenazine 

Relevant articles and documents

Selective Inhibitors of Human Liver Carboxylesterase Based on a β-Lapachone Scaffold: Novel Reagents for Reaction Profiling

Carboxylesterases (CEs) are ubiquitous enzymes that are responsible for the metabolism of xenobiotics, including drugs such as irinotecan and oseltamivir. Inhibition of CEs significantly modulates the efficacy of such agents. We report here that β-lapachone is a potent, reversible CE inhibitor with Ki values in the nanomolar range. A series of amino and phenoxy analogues have been synthesized, and although the former are very poor inhibitors, the latter compounds are highly effective in modulating CE activity. Our data demonstrate that tautomerism of the amino derivatives to the imino forms likely accounts for their loss in biological activity. A series of N-methylated amino derivatives, which are unable to undergo such tautomerism, were equal in potency to the phenoxy analogues and demonstrated selectivity for the liver enzyme hCE1. These specific inhibitors, which are active in cell culture models, will be exceptionally useful reagents for reaction profiling of esterified drugs in complex biological samples.

HEAT SHOCK PROTEIN 90 INHIBITORS, METHODS OF PREPARING SAME, AND METHODS FOR THEIR USE

Novel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors are disclosed. These compounds are useful in treating and preventing cancer and other Hsp90-related diseases and conditions, such as inflammation and neurodegenerative disorders. Methods of treating and preventing cancer and other Hsp90 related diseases and conditions are disclosed that include administering to the subject a therapeutically effective amount of an Hsp90 inhibitor. Methods of preparing the novel Hsp90 inhibitors are also provided.