69123-90-6 Usage
Description
4-Amino-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidin-2-one is a complex organic compound characterized by its unique molecular structure. It is a derivative of pyrimidinones, which are known for their diverse biological activities and potential applications in the pharmaceutical industry. 4-Amino-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidin-2-one features a fluorinated and hydroxylated oxolane ring, as well as an amino group and an iodine atom, which may contribute to its specific properties and interactions with biological targets.
Uses
4-Amino-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidin-2-one is used as an antiviral compound for inhibiting the DNA replication of herpes simplex virus (HSV). Its unique molecular structure allows it to selectively target and interfere with the viral replication process, making it a potential therapeutic agent for treating HSV infections.
Used in Pharmaceutical Industry:
4-Amino-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidin-2-one is used as a pharmaceutical candidate for the development of new antiviral drugs. Its specific molecular features and antiviral activity make it a promising compound for further research and development in the fight against herpes simplex virus and potentially other viral infections.
Check Digit Verification of cas no
The CAS Registry Mumber 69123-90-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,9,1,2 and 3 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 69123-90:
(7*6)+(6*9)+(5*1)+(4*2)+(3*3)+(2*9)+(1*0)=136
136 % 10 = 6
So 69123-90-6 is a valid CAS Registry Number.
InChI:InChI=1/C9H11FIN3O4/c10-5-6(16)4(2-15)18-8(5)14-1-3(11)7(12)13-9(14)17/h1,4-6,8,15-16H,2H2,(H2,12,13,17)
69123-90-6Relevant articles and documents
Synthesis of DNA oligos containing 2′-deoxy-2′-fluoro-d- arabinofuranosyl-5-carboxylcytosine as hTDG inhibitor
Dai, Qing,Lu, Xingyu,Zhang, Liang,He, Chuan
, p. 5145 - 5151 (2012/08/13)
As an important step of the active demethylation of 5-methylcytosine (5mC), human thymine DNA glycosylase (hTDG) efficiently excises 5-carboxylcytosine (5caC) from double-stranded DNA (dsDNA). Here, we present synthesis of DNA oligos containing a 2′-deoxy-2′-fluoro-d-arabinofuranosyl-5- carboxylcytidine (F-5caC) modification that act as hTDG inhibitors. The glycosylase activity assay showed that F-5caC oligos were resistant to excision by the hTDG catalytic domain (hTDGcat, residues 111-308) and they could inhibit the excision of DNA oligos containing 5caC. The electrophoretic mobility shift assay confirmed that DNA oligos containing F-5caC could bind well with unmodified hTDGcat to form a stable complex, which makes it possible to obtain the crystal structure of the complex to reveal details on how hTDGcat recognizes the DNA substrate.
Nucleosides. 123. Synthesis of Antiviral Nucleosides: 5-Substituted 1-(2-Deoxy-2-halogeno-β-D-arabinofuranosyl)cytosines and -uracils. Some Structure-Activity Relationships
Watanabe, Kyoichi A.,Su, Tsann-Long,Klein, Robert S.,Chu, Chung K.,Matsuda, Akira,et al.
, p. 152 - 156 (2007/10/02)
The syntheses of several 2'-halogeno-5-substituted-arabinofuranosylcytosines and -uracils are described, and relationships of structure to anti herpes virus activity in vitro were examined.Those arabinonucleosides containing the 2'-fluoro function exhibit
