69123-95-1 Usage
Description
2',5-difluoro-2'-deoxy-1-arabinosyluracil, also known as gemcitabine, is a nucleoside analog and chemotherapy drug that is used to treat various forms of cancer. It works by inhibiting the growth of cancer cells and preventing the replication of their DNA.
Uses
Used in Oncology:
2',5-difluoro-2'-deoxy-1-arabinosyluracil is used as an anticancer agent for the treatment of various forms of cancer, including breast, lung, pancreatic, and bladder cancer. It is effective in both first-line and adjuvant treatment of certain cancers and is often used in combination with other chemotherapy drugs.
Used in Drug Administration:
2',5-difluoro-2'-deoxy-1-arabinosyluracil is administered intravenously and is converted into its active form within the body. It has been found to be well-tolerated in many patients, with common side effects including nausea, vomiting, and low blood cell counts.
Check Digit Verification of cas no
The CAS Registry Mumber 69123-95-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,9,1,2 and 3 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 69123-95:
(7*6)+(6*9)+(5*1)+(4*2)+(3*3)+(2*9)+(1*5)=141
141 % 10 = 1
So 69123-95-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H10F2N2O5/c10-3-1-13(9(17)12-7(3)16)8-5(11)6(15)4(2-14)18-8/h1,4-6,8,14-15H,2H2,(H,12,16,17)/t4-,5+,6-,8-/m0/s1
69123-95-1Relevant articles and documents
A general synthesis of 2′-deoxy-2′-[18F]fluoro-1-β-D- arabinofuranosyluracil and its 5-substituted nucleosides
Alauddin, Mian M.,Conti, Peter S.,Fissekis, John D.
, p. 285 - 289 (2007/10/03)
Several 2′-deoxy-2′-[18F]fluoro-1-β-D- arabinofuranosyluracil derivatives have been synthesized. Coupling of 1-bromo-2-deoxy-2-[18F]fluoro-3,5-di-O-benzoyl-α-D- arabinofuranose 2 with protected uracil derivatives 3a-e followed by hydrolysis and high-performance liquid chromatography purification produced the radiolabeled nucleosides 4a-e in 15-30% yield (d. c.), > 99% radiochemical purity and 55.5-103.6 GBq/μmol specific activities. Copyright
5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
-
, (2008/06/13)
Pyrimidine nucleosides exhibiting anti-viral and anti-tumor effects have the formula STR1 wherein A is OR3, SR3, NR3 R4 or NHacyl wherein R3 and R4 are the same or different and are hydroge
