69139-24-8Relevant articles and documents
Synthesis, Spectral Characterization, and In Vitro Biological Evaluation of Some Novel Isoquinolinone-based Heterocycles as Potential Antitumor Agents
Hekal, Mohamed H.,Abu El-Azm, Fatma S. M.,Sallam, Hanan A.
, p. 795 - 803 (2019/02/03)
A series of new N-substituted isoquinolin-1,3-dione derivatives were prepared, starting from reaction of (Z)-4-((E)-3-phenylallylidene)isochromane-1,3-dione 4 with different nitrogen nucleophiles. The assigned structures of the prepared compounds were elucidated by spectral methods (IR, 1H NMR, 13C NMR, and mass spectroscopy). Some of the newly prepared compounds were tested in vitro against a panel of three human tumor cell lines, namely, hepatocellular carcinoma (liver) HepG2, colon cancer HCT-116, and mammary gland breast MCF-7. Also, they were tested as antioxidants. Some of the tested compounds showed very strong cytotoxic activity with respect to the standard.
Effect of the Structure of 1-Aza-1,3-dienes on 1,2- Versus 3,4-Selectivity in Cycloaddition Reactions with Homophthalic Anhydride
Georgieva, Angelina,Spassov, Stefan,Stanoeva, Elena,Topalova, Ivanka,Tchanev, Christo
, p. 148 - 149 (2007/10/03)
The reaction of homophthalic anhydride 1 with N-(cinnamylidene)tritylamine 2a proceeds as a 3,4-cycloaddition to give 4-oxo-1,2,3,4-tetrahydronaphthalene-1-carboxylic acids 3, with N-(cinnamylidene)benzylamine 2b as a 1,2-cycloaddition with the predominant formation of a 1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid, and with either 2a or cinnamaldehyde in the presence of Et3N with the formation of a 2-oxonaphtho[1,2-b]pyran-6-carboxylic acid.