6921-40-0

Basic information

• Product Name: 1-Azidonaphthalene
• Synonyms: 1-Azidonaphthalene;dicaesium 4,4'-methanediylbis(3-hydroxynaphthalene-2-carboxylate)
• CAS NO: 6921-40-0
• Molecular Formula: C₁₀H₇N₃
• Molecular Weight: 169.1827
• Mol File: 6921-40-0.mol
• Article Data: 64

Chemical Properties

• Melting Point: 12°C
• Boiling Point: 288.47°C (rough estimate)
• Flash Point: °C
• Appearance: /
• Density: 1.1713
• Refractive Index: 1.6550
• CAS DataBase Reference: 1-Azidonaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Azidonaphthalene(6921-40-0)
• EPA Substance Registry System: 1-Azidonaphthalene(6921-40-0)

Safety Data

• Hazardous Substances Data: 6921-40-0(Hazardous Substances Data)

Usage

Type of compound

Organic compound

Structure

Naphthalene ring with an azido group attached to the 1-position

Applications

a. Photoaffinity label
b. Photoremovable protecting group in organic chemistry

Photochemical property

Undergoes photochemical reactions upon exposure to ultraviolet light

Reaction outcome

Releases nitrogen gas

Utility

Valuable tool in biochemical and pharmaceutical research

Usage

Selectively label and modify biomolecules such as proteins and nucleic acids

Safety

Potentially hazardous compound

Precaution

Should be handled with care and proper safety measures

InChI:InChI=1/C10H7N3/c11-13-12-10-7-3-5-8-4-1-2-6-9(8)10/h1-7H

Upstream product

• 134-32-7 1-amino-naphthalene 
• 91-20-3 naphthalene 
• 86-57-7 1-Nitronaphthalene 
• 90-14-2 1-Iodonaphthalene 
• 39834-40-7 trans-2-bromo-1,2,3,4-tetrahydronaphthalen-1-ol 
• 13922-41-3 1-Naphthylboronic acid 

Downstream Products

• 34774-85-1 1-amino-2-(methylthiomethyl)naphthalene 
• 134-32-7 1-amino-naphthalene 
• 110678-64-3 (1-(naphthalen-1-yl)-1H-1,2,3-triazole-4,5-diyl)bis(phenylmethanone) 
• 91165-92-3 ethyl 1-(1-naphthyl)-1H-1,2,3-triazole-5-carboxylate 
• 91165-90-1 ethyl 1-(1-naphthyl)-1H-1,2,3-triazole-4-carboxylate 
• 7664-41-7 ammonia 
• 2243-55-2 1-(1-naphthyl)hydrazine 
• 70292-10-3 5-methyl-1-(naphthalen-1-yl)-1H-1,2,3-triazole-4-carboxylic acid 
• 1169853-12-6 C₃₂H₂₁N₃O₂ 
• 1169853-30-8 C₃₆H₃₁N₄O⁽¹⁺⁾*Cl^(1-) 
• 90-30-2 N-phenyl-1-naphthylamine 
• 113423-89-5 1-(1-naphthyl)-1H-1,2,3-triazole-4-carboxylic acid 
• 81945-58-6 1-(1'H-1',2',3'-triazolyl)naphthalene 
• 6281-00-1 N-butylnaphthalen-1-amine 

Relevant articles and documents

A highly selective fluorescent sensor for mercury (II) ion based on Bodipy and Calix[4]arene bearing triazolenaphthylene groups; synthesis and photophysical investigations

A highly selective and sensitive fluorescent sensor for mercury ion has been obtained from a combination of Bodipy and Calix[4]arene derived by click chemistry. The structural characterization of all compounds had been carried out by FT-IR, 1H

The synthesis and crystal structure of 5-methyl-1-(1-naphthyl)-1,2,3- triazol-4-carboxyl acid

5-Methyl-1-(1-naphthyl)-1,2,3-triazol-4-carboxyl acid 3 was synthesized from 1-aminonaphthalene. The yielded product 3 was investigated with X-ray crystallographic, NMR, MS and IR techniques. Compound 3, C14H 11N3O2, Mr = 253.26, crystallizes in the orthorhombic space group Pbca with unit cell parameters a = 10.068(2), b = 12.353(2), c = 20.102(4) A, V = 2500.1(8) A3, Z = 8, Dx = 1.346 Mgm-3. The final R was 0.0474. The molecular packing is stabilized by intermolecular O-H???N interactions.

Synthesis of new chrysin derivatives with substantial antibiofilm activity

Abstract: Multidrug resistance mechanism of microorganisms towards conventional antimicrobials nowadays faces a common health problem. So, searching and development of new antibacterials are in the frontier areas of biochemistry. Functionalizations of various natural products or synthesis of compounds through molecular modeling followed by virtual screening are the ways to obtain potential leads. Chrysin is one of the plant secondary metabolites and is ubiquitously present in majority of plants. It has multi-dimensional potentiality however, with a very low bioavailability causing a very low efficacy. Very few chrysin derivatives possessing antimicrobial activity with a low anti-biofilm efficacy have been found in the literature. Thus, it has been attempted to synthesize a series of new chrysin derivatives (CDs). In this study, twenty-two new derivatives have been synthesized via its 7-OH modulation and antibiofilm activity was evaluated against a model bacterium viz. Escherichia coli MTCC 40 (Gram negative). Eleven CDs coded as 2a, 2b, 2c, 2e, 2f, 2g, 2h, 2i, 3j, 3k and 3l have been found more potent compared to chrysin (precursor of CDs) against planktonic form of E. coli. Biofilm inhibition studies indicated a noteworthy results for 2a (93.57%), 2b (92.14%), 2f (92.14%) and 3l (93.57%) compared to chrysin (33.57%). E. coli motility was also highly restricted by 2a, 2b, 2f and 3l than chrysin at their sub-inhibitory concentrations. Solubility studies indicated an extended-release of 2a, 2b, 2f and 3l in physiological systems. Relatively higher bioavailability of 2a, 2b, 2f and 3l than chrysin was revealed from the dissolution experiments and was further validated through in silico ADME-based SAR analysis. Hence, this study is more interesting in regard to antibacterial potentiality of chrysin derivatives against Escherichia coli MTCC 40 (Gram negative). Thus, this article might be useful for further design and development of new leads in the context of biofilm-associated bacterial infections. Graphic abstract: [Figure not available: see fulltext.].

A general procedure for carbon isotope labeling of linear urea derivatives with carbon dioxide

Carbon isotope labeling is a traceless technology, which allows tracking the fate of organic compounds either in the environment or in living organisms. This article reports on a general approach to label urea derivatives with all carbon isotopes, including14C and11C, based on a Staudinger aza-Wittig sequence. It provides access to all aliphatic/aromatic urea combinations.