6925-00-4

Basic information

• Product Name: QUINOXALINE-6-CARBOXYLIC ACID
• Synonyms: 6-QUINOXALINECARBOXYLIC ACID;AKOS BBS-00001971;AKOS BBS-00000436;IFLAB-BB F1716-0520;RARECHEM AM LA 0027;QUINOXALINE-6-CARBOXYLIC ACID;TIMTEC-BB SBB000185;CHINOXALIN-6-CARBONSAEURE
• CAS NO: 6925-00-4
• Molecular Formula: C₉H₆N₂O₂
• Molecular Weight: 174.16
• Product Categories: Carboxylic Acids;Quinolines, Isoquinolines & Quinoxalines;Carboxylic Acids;Quinolines, Isoquinolines & Quinoxalines;Aromatics;Heterocycles;Intermediates;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Quinoxalines
• Mol File: 6925-00-4.mol
• Article Data: 13

Chemical Properties

• Melting Point: 250 °C
• Boiling Point: 355.1 °C at 760 mmHg
• Flash Point: 168.559 °C
• Appearance: Tan solid
• Density: 1.421 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.697
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
• PKA: 3.22±0.30(Predicted)
• CAS DataBase Reference: QUINOXALINE-6-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: QUINOXALINE-6-CARBOXYLIC ACID(6925-00-4)
• EPA Substance Registry System: QUINOXALINE-6-CARBOXYLIC ACID(6925-00-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 6925-00-4(Hazardous Substances Data)

Usage

Description

QUINOXALINE-6-CARBOXYLIC ACID is an organic compound with the chemical formula C8H5N2O2. It is a tan solid and serves as an intermediate in the synthesis of various pharmaceutical compounds. Its structure includes a quinoxaline ring fused with a carboxylic acid group, which contributes to its reactivity and potential applications in the chemical and pharmaceutical industries.

Uses

Used in Pharmaceutical Industry:
QUINOXALINE-6-CARBOXYLIC ACID is used as an intermediate for the production of antiprotozoal agents. It plays a crucial role in the synthesis of drugs that target and combat protozoan parasites, which are responsible for various diseases in humans and animals.
As an intermediate, QUINOXALINE-6-CARBOXYLIC ACID is used for the development of new drugs with potential applications in treating protozoan infections. Its chemical properties, such as the presence of the quinoxaline ring and carboxylic acid group, make it a versatile building block for the creation of novel antiprotozoal agents.

InChI:InChI=1/C9H6N2O2/c12-9(13)6-1-2-7-8(5-6)11-4-3-10-7/h1-5H,(H,12,13)

Upstream product

• 141-43-5 ethanolamine 
• 619-05-6 3,4-diaminobenzoic acid 
• 107-83-5 2-Methylpentane 
• 23088-23-5 methyl quinoxaline-6-carboxylate 
• 37466-90-3 ethyl 3,4-diaminobenzoate 
• 131543-46-9 Glyoxal 
• 517-21-5 glyoxal sodium bisulfite 
• 6924-72-7 Chinoxalin-6-carbonsaeure-ethylester 

Downstream Products

• 103029-77-2 7-hydroxy-quinoxaline-6-carboxylic acid 
• 875558-38-6 N-methoxy-N-methylquinoxaline-6-carboxamide 
• 83570-42-7 1-(quinoxalin-6-yl)ethan-1-one 
• 1425485-86-4 C₁₉H₁₇F₂N₃O₃S₂ 
• 1425485-82-0 C₁₈H₁₄F₃N₃O₃S 
• 1425486-29-8 N-(propylsulfonyl)-N-(2,4,5-trifluoro-3-(quinoxaline-6-carbonyl)phenyl)propane-1-sulfonamide 
• 1425487-57-5 (3-amino-2,5,6-trifluorophenyl)(quinoxalin-6-yl)methanone 
• 1425486-19-6 C₁₉H₁₃F₃N₄O₃S 
• 1425486-13-0 C₂₄H₁₈F₃N₃O₃S 
• 1425486-07-2 C₂₁H₂₀F₃N₃O₅S 
• 1425485-97-7 C₂₂H₁₈F₃N₅O₃S 
• 1425485-95-5 C₂₄H₁₇ClF₃N₃O₃S 
• 1425486-40-3 N-(3-(3-(4-chlorophenyl)quinoxaline-6-carbonyl)-2,4,5-trifluorophenyl)-N-(propylsulfonyl)propane-1-sulfonamide 
• 1425486-38-9 tert-butyl (3-(3-(4-chlorophenyl)quinoxaline-6-carbonyl)-2,4,5-trifluorophenyl)carbamate 

Relevant articles and documents

Triketone compound containing quinoxaline structure, and preparation method and application thereof

The invention belongs to the technical field of medicine synthesis, and particularly relates to a triketone compound containing a quinoxaline structure, and a preparation method and an application thereof. The quinoxaline-containing triketone compound has a structure represented by general formula (I). The preparation method is mainly characterized in that a compound with a structure represented by formula (II) is contacted in the presence of an alkali and a solvent, and R1, R2, R3 and R4 in the formulas are respectively defined in the description. The quinoxaline-containing triketone compoundhas high herbicidal activity, and especially has an excellent effect of preventing and controlling broadleaf weeds and/or gramineous weeds, and the prevention and control effect is even better than that of some commercial herbicides sold in the market.

Activity of novel quinoxaline-derived chalcones on in vitro glioma cell proliferation

Gliomas are the most common and devastating tumors of the central nervous system (CNS). Many pieces of evidence point out the relevance of natural compounds for cancer therapy and prevention, including chalcones. In the present study, eight synthetic quin

5(Z)-5-(6-QUINOXALINYLMETHYLIDENE)-2-[(2,6-DICHLOROPHENYL)AMINO]-1,3-THIAZOL-4(5H)-ONE

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