692890-13-4

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-[3-[3-(carboxymethyl)phenoxy]propyl]-, 1-(1,1-dimethylethyl) ester
• CAS NO: 692890-13-4
• Molecular Formula: C21H31NO5
• Molecular Weight: 377.481
• Mol File: 692890-13-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-[3-[3-(carboxymethyl)phenoxy]propyl]-, 1-(1,1-dimethylethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-[3-[3-(carboxymethyl)phenoxy]propyl]-, 1-(1,1-dimethylethyl) ester(692890-13-4)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-[3-[3-(carboxymethyl)phenoxy]propyl]-, 1-(1,1-dimethylethyl) ester(692890-13-4)

Safety Data

• Hazardous Substances Data: 692890-13-4(Hazardous Substances Data)

Upstream product

• 42058-59-3 3-hydroxy-benzeneacetic acid, methyl ester 
• 156185-63-6 N-Boc-piperidin-4-yl-propanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2629-72-3 4-(3-Hydroxypropyl)pyridine 
• 692890-07-6 methyl 3-(3-(N-Boc-piperidin-4-yl)-propoxy)-phenylacetate 

Downstream Products

• 692883-31-1 2-(3-(3-(piperidin-4-yl)-propoxy)-phenyl)-N-(4-pyridin-4-yl-thiazol-2-yl)-acetamide 
• 692884-29-0 2-(3-(3-(N-methyl-piperidin-4-yl)-propoxy)-phenyl)-N-(4-pyridin-4-yl-thiazol-2-yl)-acetamide 
• 692891-81-9 2-(3-(3-(N-Boc-piperidin-4-yl)-propoxy)-phenyl)-N-(4-pyridin-4-yl-thiazol-2-yl)-acetamide 

Relevant articles and documents

ROCK inhibitors 2. Improving potency, selectivity and solubility through the application of rationally designed solubilizing groups

Solubilizing groups have been frequently appended to kinase inhibitor drug molecules when solubility is insufficient for pharmaceutical development. Such groups are usually located at substitution sites that have minimal impact on target activity. In this report we describe the incorporation of solubilizing groups in a class of Rho kinase (ROCK) inhibitors that not only confer improved solubility, but also enhance target potency and selectivity against a closely related kinase, PKA.

AZAINDOLES USEFUL AS INHIBITORS OF ROCK AND OTHER PROTEIN KINASES

The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

COMPOSITIONS USEFUL AS INHIBITORS OF ROCK AND OTHER PROTEIN KINASES

The present invention relates to substitute thiazole and thiophene derivatives useful as inhibitors of rock and other protein kinaeses. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders, including proliferative, cardiac and neurodegenerative diseases.