69311-30-4

Basic information

• Product Name: 5-benzyl-3,4-dihydro-2H-pyrrole
• CAS NO: 69311-30-4
• Molecular Formula: C₁₁H₁₃N
• Molecular Weight: 159.2276
• Mol File: 69311-30-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 257.9°C at 760 mmHg
• Flash Point: 101.5°C
• Density: 1.01g/cm³
• Vapor Pressure: 0.0229mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: 5-benzyl-3,4-dihydro-2H-pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-benzyl-3,4-dihydro-2H-pyrrole(69311-30-4)
• EPA Substance Registry System: 5-benzyl-3,4-dihydro-2H-pyrrole(69311-30-4)

Safety Data

• Hazardous Substances Data: 69311-30-4(Hazardous Substances Data)

Upstream product

• 1589-82-8 phenylmagnesium bromide 
• 5332-06-9 4-bromobutanenitrile 
• 24463-87-4 (5-chloropent-1-ynyl)benzene 
• 536-74-3 phenylacetylene 
• 127808-49-5 5-phenylpent-4-yn-1-amine 
• 101-97-3 Ethyl 2-phenylethanoate 
• 628-20-6 4-Chlorobutyronitrile 
• 152711-26-7 3-phenylacetyl-1-vinyl-pyrrolidin-2-one 
• 6921-34-2 benzylmagnesium chloride 

Downstream Products

• 35840-91-6 2-benzylpyrrolidine 
• 116993-29-4 6-n-butyl-7-hydroxy-8-phenyl-2,3-dihydro-1H-indolizin-5-one 
• 104765-64-2 6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin 
• 823821-72-3 N-(4-oxo-5-phenylpentyl)acetamide 
• 882696-35-7 2-benzyl-1-(phenylsilyl)pyrrolidine 

Relevant articles and documents

Cyclooxygenase-1/2 (COX-1/COX-2) and 5-lipoxygenase (5-LOX) inhibitors of the 6,7-diaryl-2,3-1H-dihydropyrrolizine type

A series of 6,7-diaryl-2,3-1H-dihydropyrrolizines was prepared as COX-1/COX-2 and 5-LOX inhibitors. The inhibition of COX-1 was evaluated using intact bovine platelets as the enzyme source, whereas LPS-stimulated human monocytes served as the enzyme source for inducible COX-2. The determination of arachidonic metabolites was performed by HPLC for COX-1 and RIA for COX-2. The balance between COX-1/COX-2 and 5-LOX inhibition can be shifted by modifying the substitution pattern of the phenyl moiety at the 6- and 7-position of the pyrrolizine nucleus. Structure-activity relationships are discussed.

Zinc-zinc bonded decamethyldizincocene Zn2(η5- C5Me5)2 as catalyst for the inter- and intramolecular hydroamination reaction

The Zn-Zn bonded compound [(η5-Cp*)2Zn 2] was investigated as catalyst for the inter- and intramolecular hydroamination reaction. High reaction rates under mild conditions were observed. This is the first application of a

Convenient synthesis of melatonin analogues: 2- and 3-substituted -N-acetylindolylalkylamines

A new method for the synthesis of 2- and 3-substituted indolylalkylamides, derivatives of melatonin, from arylhydrazines and amidoketones by the Fischer reaction was elaborated. The amidoketones can be easily prepared from cyclic imines by reaction with acylpyridinium chloride. This method is a one-step synchronous creation of the selected alkylamide fragment and the indole core. Variation of the arylhydrazines create the desired substituents in the carbocycle of indolylalkylamides and suitable choice of amidoketone can direct the amidoalkyl chain to the 2- or 3-position of the indole. Graphical Abstract