6933-31-9

Basic information

• Product Name: Methanone, (2-chlorophenyl)-2-thienyl-
• CAS NO: 6933-31-9
• Molecular Formula: C11H7ClOS
• Molecular Weight: 222.695
• Mol File: 6933-31-9.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Methanone, (2-chlorophenyl)-2-thienyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (2-chlorophenyl)-2-thienyl-(6933-31-9)
• EPA Substance Registry System: Methanone, (2-chlorophenyl)-2-thienyl-(6933-31-9)

Safety Data

• Hazardous Substances Data: 6933-31-9(Hazardous Substances Data)

Upstream product

• 42916-70-1 1-(2-chlorophenyl)-pentan-1-one 
• 5713-61-1 thiophen-2-yl magnesium bromide 
• 188290-36-0 thiophene 
• 609-65-4 o-chlorobenzoyl chloride 
• 3437-95-4 2-Iodothiophene 
• 201230-82-2 carbon monoxide 
• 3900-89-8 2-Chlorobenzeneboronic acid 
• 527-72-0 2-thiophenylcarboxylic acid 
• 135887-25-1 (2-chlorophenyl)-(thiophen-2-yl)methanol 
• 89-98-5 2-chloro-benzaldehyde 
• 118-91-2 ortho-chlorobenzoic acid 

Downstream Products

• 687610-55-5 (2-chloro)-phenyl 2-thienyl O-(diethylaminoethyl)-ketone oxime 
• 135887-29-5 C₂₂H₁₆Cl₂OS₂ 
• 135887-25-1 (2-chlorophenyl)-(thiophen-2-yl)methanol 

Relevant articles and documents

Ni and Cu-catalyzed one pot synthesis of unsymmetrical 1,3-di(hetero)aryl-1: H -indazoles from hydrazine, o -chloro (hetero)benzophenones, and (hetero)aryl bromides

The nickel-catalyzed cyclization of in situ generated ortho-chlorobenzophenone hydrazone derivatives, to afford 3-(hetero)aryl-1H-indazoles, is documented for the first time. The product 1H-indazoles can be transformed subsequently in a one-pot procedure into 1,3-di(hetero)aryl-1H-indazoles via copper-catalyzed N-arylation with (hetero)aryl bromides.

TFAA/H3PO4-Mediated C-2 acylation of thiophene: A direct synthesis of known and novel thiophene derivatives of pharmacological interest

A number of aliphatic and aromatic carboxylic acids were reacted with thiophene in the presence of trifluoroacetic anhydride and H3PO 4 to give a variety of acylated thiophenes in good to excellent yields. The methodology was used to prepare known nonsteroidal anti-inflammatory drug-based novel compounds of potential pharmacological significances. Molecular modeling studies were carried out by using nonsteroidal anti-inflammatory drug-based thiophene derivatives to assess their cyclooxygenase inhibiting potential in silico. On the basis of docking studies followed by subsequent in vitro assay, indomethacin-based thiophene derivative was identified as a novel cyclooxygenase-2 inhibitor with balanced selectivity.

Catalytic Friedel-Crafts acylation: Magnetic nanopowder CuFe 2O4 as an efficient and magnetically separable catalyst

Catalytic regioselective Friedel-Crafts acylation of an array of anisoles/arenes with various acid chlorides using 5-20 mol % of magnetic nanopowder CuFe2O4 is reported. Unlike the conventional Friedel-Crafts reactions, which are catalyzed by moisture sensitive homogeneous catalysts/promoters, the nanopowder CuFe2O4 catalyst is moisture insensitive and the product/ketone-catalyst isolation is easily achieved using the magnetic properties of CuFe2O4.