6933-50-2Relevant articles and documents
Organocatalytic Enantioselective Construction of Chiral Azepine Skeleton Bearing Multiple-Stereogenic Elements
Huang, Shengli,Wen, Haojun,Tian, Yuhong,Wang, Pengfei,Qin, Wenling,Yan, Hailong
, p. 21486 - 21493 (2021)
Enantioselective construction of molecules bearing multiple stereogenic elements is increasingly related to the synthesis of enantiopure natural products, pharmaceuticals, and functional materials. However, atom-economical and enantioselective approaches
A 4 - hydroxy-carbazole new synthesis method (by machine translation)
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Paragraph 0009-0011, (2019/05/16)
The invention belongs to the field of organic synthesis, in particular to a 4 - hydroxy-carbazole new synthesis method. The the new synthesis method to bromo nitrobenzene and neighbouring iodine anisole as raw material 3 step by the reaction of 4 - hydroxy-carbazole. The invention uses a 4 - hydroxy-carbazole new synthesis method, can significantly speed up the reaction rate and to improve the yield, not only reduces the cost, the protection of the environment, and the operation is simple, after treatment is convenient, and is suitable for industrial production. (by machine translation)
Synthesis of the Carbazole Scaffold Directly from 2-Aminobiphenyl by Means of Tandem C–H Activation and C–N Bond Formation
Bj?rsvik, Hans-René,Elumalai, Vijayaragavan
, p. 5474 - 5479 (2016/11/25)
An efficient method for the synthesis of the carbazole scaffold was designed and investigated. The method was developed to produce substituted carbazoles by an intramolecular combination of a free amine group and an arene. The steps of the method involved tandem Pd-catalyzed C–H activation and intramolecular C–N bond formation. The method showed good functional group tolerance, and substituent(s) could be on either of the two rings or on both of the two rings of the 2-aminobiphenyl substrate. After ring closure, the reduced Pd catalyst was oxidized to PdIIby hydrogen peroxide. The novel method was also demonstrated to operate excellently with the corresponding 2-N-acetylaminobiphenyls.