6941-24-8

Basic information

• Product Name: N-tert-butylcyclohexanecarboxamide
• CAS NO: 6941-24-8
• Molecular Formula: C₁₁H₂₁NO
• Molecular Weight: 183.2905
• Mol File: 6941-24-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 319.3°C at 760 mmHg
• Flash Point: 189.6°C
• Density: 0.934g/cm³
• Vapor Pressure: 0.000342mmHg at 25°C
• Refractive Index: 1.466
• CAS DataBase Reference: N-tert-butylcyclohexanecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-butylcyclohexanecarboxamide(6941-24-8)
• EPA Substance Registry System: N-tert-butylcyclohexanecarboxamide(6941-24-8)

Safety Data

• Hazardous Substances Data: 6941-24-8(Hazardous Substances Data)

Upstream product

• 507-19-7 t-butyl bromide 
• 766-05-2 cyclohexane carbonitrile 
• 75-65-0 tert-butyl alcohol 
• 119072-55-8 tert-butylisonitrile 
• 4545-18-0 N'-cyclohexylidene-4-methylbenzene-1-sulfonohydrazide 
• 108-85-0 1-bromocyclohexane 
• 1609-86-5 Tert-butyl isocyanate 
• 953-91-3 cyclohexyl tosylate 
• 626-62-0 Cyclohexyl iodide 
• 2043-61-0 cyclohexanecarbaldehyde 
• 5894-65-5 N-t-butylbenzamide 
• 7337-45-3 N-tert-butylaminoborane 
• 98-89-5 Cyclohexanecarboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

AMINE-BORANES AS BIFUNCTIONAL REAGENTS FOR DIRECT AMIDATION OF CARBOXYLIC ACIDS

The present invention generally relates to a process for selective and direct activation and subsequent amidation of aliphatic and aromatic carboxylic acids to afford an amide R3CONR1R2. That the process is capable of delivering gaseous or low-boiling point amines provides a major advantage over existing methodologies, which involves an intermediate of triacyloxyborane-amine complex [(R3CO2)3—B—NHR1R2]. This procedure readily produces primary, secondary, and tertiary amides, and is compatible with the chirality of the acid and amine involved. The preparation of known pharmaceutical molecules and intermediates has also been demonstrated.

Mild and Selective Rhodium-Catalyzed Transfer Hydrogenation of Functionalized Arenes

Diboron-mediated rhodium-catalyzed transfer hydrogenation of functionalized arenes is reported. In addition to good functional group tolerance, the reaction features operational simplicity and controllable chemoselectivity. The general applicability of this procedure is demonstrated by the selective hydrogenation of a range of arenes, including functionalized benzenes, biphenyls, and polyaromatics.

A convenient synthesis of N-tert-butyl amides by the reaction of di-tert-butyl dicarbonate and nitriles catalyzed by Cu(OTf)2

The utility of Cu(OTf)2 as the catalyst for the synthesis of a series of N-tert-butyl amides in excellent isolated yields via the reaction of nitriles (alkyl, aryl, benzyl, and furyl nitriles) with di-tert-butyl dicarbonate is described. Cu(OTf)2 is a highly stable and efficient catalyst for the present Ritter reaction under solvent-free conditions at room temperature.