69411-05-8

Basic information

• Product Name: 3-AMINO-5-CHLOROBENZOTRIFLUORIDE
• Synonyms: 3-AMINO-5-CHLORO-1-TRIFLUOROMETHYLBENZENE HYDROCHLORIDE;3-AMINO-5-CHLOROBENZOTRIFLORIDE;3-AMINO-5-CHLOROBENZOTRIFLUORIDE;3-CHLORO-5-(TRIFLUOROMETHYL)ANILINE;3-Chloro-5-trifluoromethylbenzenamine;3-AMino-5-chlorobenzotrifluoride[3-Chloro-5-(trifluoroMethyl)aniline]
• CAS NO: 69411-05-8
• Molecular Formula: C₇H₅ClF₃N
• Molecular Weight: 195.57
• EINECS: 273-989-1
• Product Categories: Fluorine series
• Mol File: 69411-05-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 218.2 °C at 760 mmHg
• Flash Point: 85.8 °C
• Appearance: yellow liquid
• Density: 1.425 g/cm³
• Vapor Pressure: 0.127mmHg at 25°C
• Refractive Index: 1.5
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.32±0.10(Predicted)
• CAS DataBase Reference: 3-AMINO-5-CHLOROBENZOTRIFLUORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-5-CHLOROBENZOTRIFLUORIDE(69411-05-8)
• EPA Substance Registry System: 3-AMINO-5-CHLOROBENZOTRIFLUORIDE(69411-05-8)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38-36-36/38
• Safety Statements: 26-36/37/39-36/37
• RIDADR: 2810
• HazardClass: IRRITANT
• Hazardous Substances Data: 69411-05-8(Hazardous Substances Data)

Usage

General Description

3-AMINO-5-CHLOROBENZOTRIFLUORIDE is a chemical compound with the molecular formula C7H5ClF3N. It is a white to pale yellow crystalline solid that is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is known to be an important building block in the production of various drugs and pesticides, as well as in the manufacture of dyes and pigments. Additionally, it is used as a reagent in organic synthesis and as a starting material for the preparation of other functionalized benzotrifluoride derivatives. 3-AMINO-5-CHLOROBENZOTRIFLUORIDE is also known by the trade name ACACIA and is classified as a hazardous substance due to its potential to cause skin and eye irritation.

InChI:InChI=1/C7H5ClF3N/c8-5-1-4(7(9,10)11)2-6(12)3-5/h1-3H,12H2

Upstream product

• 401-93-4 5-chloro-3-trifluoromethyl-nitrobenzene 

Downstream Products

• 300842-56-2 1-(5-Chloro-3-trifluormethyl-anilino)-4-(4-pyridyl-methyl)-phthalazine 
• 884340-21-0 phenyl 3-chloro-5-(trifluoromethyl)phenylcarbamate 

Relevant articles and documents

FUSED HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION

Disclosed are fused heterocyclic compounds of Formula (I) or pharmaceutically-acceptable salts or stereoisomers thereof. Also disclosed are methods of using such compounds in the treatment of at least one androgen receptor-associated condition, such as, for example, cancer, and pharmaceutical compositions comprising such compounds.

Isoquinoline derivatives with angiogenesis inhibiting activity

The invention relates to compounds of formula I wherein r is from 0 to 2; n is from 0 to 2; m is from 0 to 4; A, B, D and E are each independently of the others N or CH, with the proviso that not more than two of those radicals are N; G is lower alkylene, —CH2—O—, —CH2—S—, —CH2—NH—, oxa (—O—), thia (—S—) or imino (—NH—), or is lower alkylene substituted by acyloxy or by hydroxy; Q is lower alkyl, especially methyl; R is H or lower alkyl; X is imino, oxa or thia; Y is lower alkyl or, especially, aryl, heteroaryl or unsubstituted or substituted cycloalkyl; and Z is amino, mono- or di-substituted amino, halogen, alkyl, substituted alkyl, hydroxy, etherified or esterified hydroxy, nitro, cyano, carboxy, esterified carboxy, alkanoyl, carbamoyl, N-mono- or N,N-di-substituted carbamoyl, amidino, guanidino, mercapto, sulfo, phenylthio, phenyl-lower alkylthio, alkylphenylthio, phenylsulfinyl, phenyl-lower alkylsulfinyl, alkylphenyl-sulfinyl, phenylsulfonyl, phenyl-lower alkanesulfonyl or alkylphenylsulfonyl, and where, if more than one radical Z is present (m≧4), the substituents Z are identical or different; and wherein the bonds indicated by a wavy line are either single bonds or double bonds; or an N-oxide of the mentioned compound, wherein one or more N atoms carry an oxygen atom; or a salt thereof. The compounds inhibit especially angiogenesis.